Efficacy of serratiopeptidase in third molar surgery. A systematic review and meta-analysis

  • Heber Arbildo-Vega Faculty of Dentistry, School of Dentistry, Universidad San Martín de Porres. Chiclayo - Peru.; Faculty of Human Medicine, School of Human Medicine, Universidad San Martín de Porres. Chiclayo - Peru.; Faculty of Human Medicine, School of Stomatology, Universidad Alas Peruanas. Lima – Peru. http://orcid.org/0000-0003-3689-7502
  • Alfredo Rendón-Alvarado Faculty of Dentistry, School of Dentistry, Universidad San Martín de Porres. Chiclayo - Peru. http://orcid.org/0000-0001-9772-4336
  • Tania Castillo-Cornock Faculty of Dentistry, School of Dentistry, Universidad San Martín de Porres. Chiclayo - Peru. http://orcid.org/0000-0001-6135-9277
  • Fredy Cruzado-Oliva Faculty of Dentistry, School of Dentistry, Universidad San Martín de Porres. Chiclayo - Peru. http://orcid.org/0000-0003-1575-0077
  • Alex Vidal-Mosquera Faculty of Dentistry, School of Dentistry, Universidad San Martín de Porres. Chiclayo - Peru. http://orcid.org/0000-0001-7575-8156
  • Hernán Vásquez-Rodrigo Faculty of Dentistry, School of Dentistry, Universidad San Martín de Porres. Chiclayo - Peru.; Faculty of Dentistry, School of Dentistry, Universidad Norbert Wiener. Lima - Peru. http://orcid.org/0000-0002-5926-6837


Objective: To determine the efficacy of serratiopeptidase in third molar surgery.
Materials and Methods: A bibliographic search was carried out until April 2022, in the biomedical databases: Pubmed/Medline, Cochrane Central Registry of Clinical Trials, Scopus, Scielo and Google Scholar. Studies reporting the ef-ficacy of serratiopeptidase in third molar surgery, which were randomized clinical trials, in English and without time limits, were included. The RoB 2.0 tool was used to assess the risk of the included studies and the GRADEPro GDT tool to assess
Results: The preliminary search yielded a total of 116 articles, discarding those that did not meet the selection criteria, leaving only 10 articles. Six articles entered a meta-analysis and found that serratiopeptidase reduces trismus but not reduce inflammation and pain after third molar surgery.
Conclusions: The literature reviewed suggests that ser-ratiopeptidase is effective in reducing trismus after third molar surgery.
Keywords: Serratiopeptidase; Molar, Third; Inflammation; Pain; Trismus; Meta-Analysis.


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How to Cite
ARBILDO-VEGA, Heber et al. Efficacy of serratiopeptidase in third molar surgery. A systematic review and meta-analysis. Journal of Oral Research, [S.l.], v. 12, n. 1, p. 348-361, dec. 2023. ISSN 0719-2479. Available at: <https://www.joralres.com/index.php/JOralRes/article/view/joralres.2023.030>. Date accessed: 24 apr. 2024. doi: https://doi.org/10.17126/joralres.2023.030.