Regeneration of a large bony lesion with advanced-platelet rich fibrin: Case Report


Introduction: This case report analyzes the regeneration potential of advanced-platelet rich fibrin (A-PRF) in large bony lesions. Advanced-platelet rich fibrin provides various growth factors which aids in faster healing.
Materials and Methods: Patient presented with peri-apical radiolucency. CBCT showed bony radiolucency in teeth 31, 32, 41, 42. A full mouth mucoperiosteal flap was raised and a cyst lining was enucleated. Apicoectomy was done with respect to 31, 32, 41, 42 along with and retrograde with a preparation of APRF clots were placed in the bony cavity.
Results: Post-op CBCT at 6 months showed a significant difference in size and bone density of the lesion.
Conclusions: Advanced-platelet rich fibrin has shown promising results in reducing the size of bony defect and periapical lesion in this case.
Keywords: Cysts; Apicoectomy; Endodoncia Regenerativa; Platelet-Rich Fibrin; Regeneration; Cone-Beam Computed Tomography.


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How to Cite
GUPTA, Ravi; SHUKLA, Sagrika. Regeneration of a large bony lesion with advanced-platelet rich fibrin: Case Report. Journal of Oral Research, [S.l.], v. 12, n. 1, p. 100-107, sep. 2023. ISSN 0719-2479. Available at: <>. Date accessed: 19 may 2024. doi: