Camellia sinensis, a natural product to support the treatment of medical and stomatological conditions

Abstract

Introduction: The tea plant, Camellia sinensis, is one of the most popular non-alcoholic beverages in the world. The main components of Camellia sinensis include amino acids, fatty acids, phenolic compounds, flavins and purine alkaloids (xanthines). For this reason, in the field of medicine, Camellia sinensis has been used as an anticancer, anxiolytic, antidiabetic, antiobesity, anti-inflammatory, analgesic, antipyretic, chemopreventive, cytotoxic and apoptogenic, genoprotective, hepatoprotective, nephroprotective, hemato-protective, and in wound healing, among other uses. Objective: To carry out a systematic review of the use of C. sinensis as supportive therapy in the treatment of oral disorders.
Materials and Methods: This systematic review was carried out following the PRISMA guidelines. The search was carried out in the PubMed, ScienceDirect and Google Academic databases. Articles from studies of Camellia sinensis were reviewed and those from a secondary source, such as literature review articles, were excluded
Results: A total of 12 full-text articles were selected for review, in which the properties of Camellia sinensis are detailed.
Conclusions: According to the bibliography reviewed, C. sinensis exhibits anticariogenic properties, applications in the treatment of dental erosion, applications in the treatment of gingivitis and bacterial plaque, and applications in the prevention of oral cancer; however, more controlled clinical trials are needed to confirm its effectiveness and safety of use.
Keywords: Camellia sinensis; Botany; Functional claim; Therapeutics; Dentistry; Systematic Review.

References

[1]. Ghabru A, Rana N, Sud R. Flavan-3-Ols and biological implication of Camellia sinensis (L) O Kuntze. J Pharmacogn Phytochem 2018; 7(3):241-248.

[2]. Ahmeda, A, Zangeneh, A, Zangeneh, M. Green synthesis and chemical characterization of gold nanoparticle synthesized using Camellia sinensis leaf aqueous extract for the treatment of acute myeloid leukemia in comparison to daunorubicin in a leukemic mouse model. Appl Organomet Chem. 2020; 34(3): 1474-1504. https://doi.org/10.1002/aoc.5290

[3]. Vishnoi H, Bodla RB, Kant R. Green Tea (Camellia sinensis) and its antioxidant property: A review. IJPSR. 2018; 9(5): 1723-36.

[4]. Niu S, Song Q, Koiwa H, Qiao D, Zhao D, Chen Z, Liu X, Wen X. Genetic diversity, linkage dise-quilibrium, and population structure analysis of the tea plant (Camellia sinensis) from an origin center, Guizhou plateau, using genome-wide SNPs developed by genotyping-by-sequencing. BMC Plant Biol. 2019;19(1):328. https://doi.org/10.1186/s12870-019-1917-5. PMID: 31337341; PMCID: PMC6652003.

[5]. Hazra A, Mahadani P, Das S, Bhattacharya S, Kumar R, Sengupta C, Das S. Insight to the ancestral rela-tions and varietal diversity of Indian tea [Camellia sinensis (L.) Kuntze] through plastid and nuclear phylogenetic markers. Genet Resour Crop Evol. 2021; 68(1): 773–783. https://doi.org/10.1007/s10722-020-01022-2

[6]. Fang R, Redfern SP, Kirkup D, Porter EA, Kite GC, Terry LA, Berry MJ, Simmonds MS. Variation of theanine, phenolic, and methylxanthine compounds in 21 cultivars of Camellia sinensis harvested in different seasons. Food Chem. 2017;220:517-526. https://doi.org/10.1016/j.foodchem.2016.09.047. Epub 2016 Sep 9. PMID: 27855934.

[7]. Li H, Wang Y, Liu J, Liu Z, Zhuang J. Genomic analyses of the crosstalk between gibberellins and brassinosteroids metabolisms in tea plant (Camellia sinensis (L.) O. Kuntze). Hortic Res. 2020; 268(1): 109368. https://doi.org/10.1016/j.scienta.2020.109368

[8]. Stadnik M, Velho A, Zorrilla S. Desarrollo sustentável na produção agroalimentar. 1a Ed. Florianópolis: CCA/UFSC editorial; 2019.

[9]. Bulnes G. Efecto de dosis de ácido giberélico y nitrato de potasio en la germinación de té (Camellia Sinensis L. Kuntze) en Leoncio Prado [tesis de título] [Tingo María] Facultad de Recursos Naturales Renovables. Universidad Nacional Agraria de la Selva; 2017.

[10]. Palacios M, Pamucena J. Efecto antibacteriano del extracto hidroalcohólico de hojas secas de Camellia sinensis L. (té verde) en cultivos de Cutibacterium acnes (Acné Vulgaris), in vitro [Tesis de título] [Lima] Facultad de Ciencias Farmacéuticas y Bioquímica. Universidad Inca Garcilaso de la Vega; 2019.

[11]. Atta M, Jafari S, Moore K. Complementary and Alternative Medicine: A Review on the Effects of Ginger, Cinnamon and Camellia Sinensis Leaf Tea in Diabetes. J Diabetes Mellit 2019; 9(1): 126-136. https://doi.org/10.4236/jdm.2019.93012

[12]. Konieczynski P, Viapiana A, Wesolowski M. Comparison of Infusions from Black and Green Teas (Camellia sinensis L. Kuntze) and Erva-mate (Ilex paraguariensis A. St.-Hil.) Based on the Content of Essential Elements, Secondary Metabolites, and Antioxidant Activity. Food Anal Methods. 2017; 10(1): 3063–70 https://doi.org/10.1007/s12161-017-0872-8

[13]. Mazur M, Ndokaj A, Jedlinski M, Ardan R, Bietolini S, Ottolenghi L. Impact of Green Tea (Camellia Sinensis) on periodontitis and caries. Systematic review and meta-analysis. Jpn Dent Sci Rev. 2021; 57:1-11. https://doi.org/10.1016/j.jdsr.2020.11.003. Epub 2021 Feb 13. PMID: 33737989; PMCID: PMC7946350.

[14]. Saeed M, Naveed M, Arif M, Kakar MU, Manzoor R, Abd El-Hack ME, Alagawany M, Tiwari R, Khandia R, Munjal A, Karthik K, Dhama K, Iqbal HMN, Dadar M, Sun C. Green tea (Camellia sinensis) and l-theanine: Medicinal values and beneficial applications in humans-A comprehensive review. Biomed Pharmacother. 2017; 95:1260-1275. https://doi.org/10.1016/j.biopha.2017.09.024. Epub 2017 Oct 6. PMID: 28938517.

[15]. Yang CS, Wang H, Sheridan ZP. Studies on prevention of obesity, metabolic syndrome, dia-betes, cardiovascular diseases and cancer by tea. J Food Drug Anal. 2018;26(1):1-13. https://doi.org/ 10.1016/j.jfda.2017.10.010. Epub 2017 Dec 1. PMID: 29389543; PMCID: PMC9332647.

[16]. Jiménez S, Lara E, Scougall R. Efecto remineralizante del Xilitol, Juniperus Communis y Camellia Sinensis adicionados en pastas dentales: Estudio in vitro. Odovtos-Int J Dent Sc 2020; 22(1): 71-79.+

[17]. Omidi J, Abdolmohammadi S. Green Tea (Camellia Sinensis) Ordinary Beverages or Medicinal Beverages: A Review. Int J Vitam Nutr Res 2019; 4(2): 98-100. https://doi.org/10.11648/j.ijbc.20190402.13.

[18]. Sutini S, Widiwurjani W, Augustien N, Suhardjono H, Guniarti G, Purwanto D, et al. In vitro culture technique of Camellia sinensis L for epicatechin production with phosphor inducer. Res J Biol Sci 2020; 25(2): 27-31

[19]. Thitimuta S, Pithayanukul P, Nithitanakool S, Bavovada R, Leanpolchareanchai J, Saparpakorn P. Camellia sinensis L. Extract and Its Potential Beneficial Effects in Antioxidant, Anti-Inflammatory, Anti-Hepatotoxic, and Anti-Tyrosinase Acti-vities. Molecules. 2017;22(3):401. https://doi.org/10.3390/molecules22030401. PMID: 28273866; PMCID: PMC6155403.

[20]. Ardiana L, Sauriasari R, Elya B. Antidiabetic Activity Studies of White Tea (Camellia sinensis (L.) O. Kuntze) Ethanolic Extracts in Streptozotocin-nico-tinamide Induced Diabetic Rats. Pharmacogn. J. 2018; 10(1):186-189.

[21]. Wang Y, Ren N, Rankin GO, Li B, Rojanasakul Y, Tu Y, Chen YC. Anti-proliferative effect and cell cycle arrest induced by saponins extracted from tea (Camellia sinensis) flower in human ovarian cancer cells. J Funct Foods. 2017; 37:310-321. https://doi.org/10.1016/j.jff.2017.08.001. Epub 2017 Aug 10. PMID: 32719725; PMCID: PMC7384602.

[22]. Unno K, Furushima D, Hamamoto S, Iguchi K, Yamada H, Morita A, Horie H, Nakamura Y. Stress-Reducing Function of Matcha Green Tea in Animal Experiments and Clinical Trials. Nutrients. 2018;10(10):1468. https://doi.org/10.3390/nu10101468. PMID:30308973; PMCID: PMC6213777.

[23]. Cayo C, Cervantes L. La actividad antibacteriana de Camellia sinensis comparada con propóleo frente al Streptococcus mutans. Rev Cubana Estomatol 2018; 57(1): e2967.

[24]. Melok AL, Lee LH, Mohamed Yussof SA, Chu T. Green Tea Polyphenol Epigallocatechin-3-Gallate-Stearate Inhibits the Growth of Streptococcus mutans: A Promising New Approach in Caries Prevention. Dent J (Basel). 2018;6(3):38. https://doi.org/10.3390/dj 6030038PMID: 30082585; PMCID: PMC6162448.

[25]. Passos VF, Melo MAS, Lima JPM, Marçal FF, Costa CAGA, Rodrigues LKA, Santiago SL. Active compounds and derivatives of camellia sinensis responding to erosive attacks on dentin. Braz Oral Res. 2018;32:e40. https://doi.org/10.1590/1807-3107bor-2018.vol32.0040. Erratum in: Braz Oral Res. 2018 Jul 10;32:e40err. PMID: 29846385.

[26]. Hagiu A, Attin T, Schmidlin PR, Ramenzoni LL. Dose-dependent green tea effect on decrease of inflammation in human oral gingival epithelial keratinocytes: in vitro study. Clin Oral Investig. 2020;24(7):2375-2383. https://doi.org/10.1007/s 00784-019-03096-4. Epub 2019 Oct 24. PMID: 31650316.

[27]. Belobrov S, Seers C, Reynolds E, Cirillo N, McCullough M. Functional and molecular effects of a green tea constituent on oral cancer cells. J Oral Pathol Med. 2019;48(7):604-610. https://doi.org/10.1111/jop.12914 Epub 2019 Jun 28. PMID: 31188490.

[28]. Yoshimura H, Yoshida H, Matsuda S, Ryoke T, Ohta K, Ohmori M, et al. The therapeutic potential of epigallocatechin 3 gallate against human oral squamous cell carcinoma through inhibition of cell proliferation and induction of apoptosis: In vitro and in vivo murine xenograft study. Mol Med Rep. 2019; 20(2):1139-1148. https://doi.org/10.3892/mmr.2019.10331

[29]. Kim MA, Kim JH, Nam OH. Tea extracts differentially inhibit Streptococcus mutans and Streptococcus sobrinus biofilm colonization depending on the steeping temperature. Biofouling. 2020;36(3):256-265. https://doi.org/10.1080/08927014.2020.1755429. Epub 2020 Apr 24. PMID: 32326756.

[30]. Kanbarkar N, Mishra S. Matrix metalloproteinase inhibitors identified from Camellia sinensis for COVID-19 prophylaxis: an in silico approach. ADV TRADIT MED (ADTM). 2021;21(1):173–88. https://doi.org/10.1007/s13596-020-00508-9. Epub 2020 Oct 6. PMCID: PMC7538275.
Published
2023-05-29
How to Cite
REYES-MANSILLA, Ricardo; CUENTAS-ROBLES, Adelmo; RAMOS-PERFECTO, Donald. Camellia sinensis, a natural product to support the treatment of medical and stomatological conditions. Journal of Oral Research, [S.l.], v. 12, n. 1, p. 24-34, may 2023. ISSN 0719-2479. Available at: <https://www.joralres.com/index.php/JOralRes/article/view/joralres.2023.003>. Date accessed: 29 mar. 2024. doi: https://doi.org/10.17126/joralres.2023.003.
Section
Reviews