Evaluation of serum and salivary transforming growth factor beta, vascular endothelial growth factor and tumor necrosis factor alpha in oral lichen planus.

  • Amira Abdelwhab Cairo University, Cairo, Egypt.| October 6 University, Giza, Egypt.
  • Mahmoud Mohamed Kandeel Cairo University, Cairo, Egypt.
  • Hala Hassan Yassin October 6 University, Giza, Egypt
  • Wesam Abdelmonem Cairo University, Cairo, Egypt
  • Olfat Gamil Shaker Cairo University, Cairo, Egypt
DOI: https://doi.org/10.17126/joralres.2020.012
Keywords: Oral lichen planus, serum, saliva, transforming growth factor beta, vascular endothelial growth factor a, tumor necrosis factor-alpha

Abstract

Introduction: Lichen planus is one of the most common oral mucosal lesions. Transforming growth factor-β (TGF- β) has a marked effect on epithelial–mesenchymal transition and immune cells function. Vascular Endothelial Growth Factor (VEGF) is a key regulator of vasculogenesis and angiogenesis. Tumor necrosis factor-α (TNF-α) mediates T-lymphocyte homing and apoptosis of epithelial cells. Objetive: The present study was conducted in order to compare the expression of serum and salivary TGF- β, VEGF, TNF-α between OLP patients and control individuals to investigate if saliva can be used as an alternative to serum for diagnostic purposes and for monitoring disease. Materials and Methods: 23 OLP patients and 23 control individuals were included to evaluate serum and salivary TGF-β, VEGF, TNF-α using ELISA kits. Five milliliters of venous blood was collected and unstimulated saliva was collected by the spitting method. Results: Serum and salivary levels of TGF- β, VEGF, TNF-α are higher in OLP patients compared to normal controls. Mean difference is higher in saliva than serum. Moreover, there was a significant difference in serum and salivary VEGF and TNF-α between symptomatic and asymptomatic groups. Conclusions: Saliva can be a used as a substitute for serum to evaluate levels of the assessed biomarkers.

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Published
2020-04-30
How to Cite
Abdelwhab, A., Kandeel, M., Yassin, H., Abdelmonem, W., & Shaker, O. (2020). Evaluation of serum and salivary transforming growth factor beta, vascular endothelial growth factor and tumor necrosis factor alpha in oral lichen planus. Journal of Oral Research, 9(2), 86-92. https://doi.org/10.17126/joralres.2020.012
Issue
Vol 9 No 2 (2020)
Section
Articles

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