Prevalence and risk factors for HPV infection in normal oral mucosa of Chilean dentistry students.

  • Rocío Aguirre Facultad de Odontología, Universidad Andrés Bello.
  • Ana Tapia Facultad de Odontología, Universidad Andrés Bello.
  • Alejandra Fernández Facultad de Odontología, Universidad Andrés Bello.
  • Mauricio Bittner Facultad de Odontología, Universidad Andrés Bello.
  • Alfredo Esguep Facultad de Odontología, Universidad Andrés Bello.
DOI: https://doi.org/10.17126/joralres.2015.075

Abstract

Aim: To determine the prevalence and risk factors for HPV infection in normal oral mucosa of Chilean dentistry students. Materials and methods: A cross-sectional study was performed. The study group was comprised of 103 individuals between 18 and 33 years old. A self-administered survey of cancer family history, sexual habits, smoking and alcohol drinking was applied. Oral mucosal samples were taken using a sterile swab. Subsequently, all samples were analyzed by polymerase chain reaction technique (PCR). Results: Results were negative for HPV detection in all analyses. Of the study population, 58% had a family history of cancer, 40.9% had had more than 3 sexual partners, 76.3% had sexual intercourse before the age of 19, 66.3% had engaged in oral sex, 69.9% drank alcohol and 20.6% were smokers. Conclusions: The group studied is exposed to various risk factors for HPV infection, so it is necessary to educate about the relationship between them and the spread of the virus. Despite the presence of risk factors, the detected prevalence of HPV was 0%.

 

References

1. Jayaprakash V, Reid M, Hatton E, Merzianu M, Rigual N, Marshall, Gill S, Frustino J, Wilding G, Loree T, Popat S, Sullivan M. Human papillomavirus types 16 and 18 in epithelial dysplasia of oral cavity and oropharynx: A meta-analysis, 1985–2010. Oral Oncol. 2011; 47(11): 1048-1054.
2. Gonzalez M, Barrera E, Herrera V, Conde L, Puerto M, Ayora G. Epidemiology of oral HPV in the oral mucosa in women without signs of oral disease from Yucatan, Mexico. Braz J Microbiol. 2015; 46(1): 301–306.
3. Fernández A, Marshall M, Esquep A. Human Papilloma Virus and oral cancer: Narrative review of the literature. J Oral Res. 2014; 3(3): 190-197.
4. Ferreccio C, Van De Wyngard V, Olcay F, Domínguez M, Puschel K, Corvalán A, Franceschi S, Snijders P. High- risk HPV infection after five years in a population-based cohort of Chilean women, Infect Agent Cancer 2011; 6(1): 21-26.
5. Beder C, Ferrer I, Santos de Farias A, Fonseca D, Morais Silva I, Monteiro Gueiros L, Tavarez A, Ross S, Carneiro J. Oral and genital HPV genotypic concordance between sexual partners. Clin Oral Investig. 2014; 18(1): 261-268.
6. Tristão W, Metzker R, de Oliveira C, Betiol J, Ribeiro J, Epidemiological study of HPV in oral mucosa through PCR. Braz J Otorhinolaryngol. 2012; 78(4): 66-70.
7. D'Souza G, Kluz N, Wentz A, Youngfellow R, Griffioen A, Stammer E, Guo Y, Xiao W, Gillison M. Oral Human Papillomavirus (HPV) Infection among Unvaccinated High-Risk Young Adults. Cancers 2014; 6(3): 1691-1704.
8. Osazuwa N. Human papillomavirus (HPV), HPV-associated oropharyngeal cancer, and HPV vaccine in the United States—Do we need a broader vaccine policy?. Vaccine 2013; 31(47): 5500-5505.
9. Gillison M, Broutian T, Pickard R, Tong Z, Xiao W, Kahle L, Graubard B, Chatuverdi A, Prevalence of Oral HPV Infection in the United States, 2009-2010. JAMA 2012; 307(7): 693-703.
10. Kreimer A, Bhatia R, Messeguer A, González P, Herrero R, Giuliano A, Oral Human Papillomavirus in Healthy Individuals: A Systematic Review of the Literature. Sex Transm Dis. 2010; 37(6): 386-391.
11. Ferreccio C, Prado R, Luzoro A, Ampuero S, Snijders P, Meijer C, Vaccarella S, Jara A, Puschel K, Robles S, Herrero R, Franceschi S, Ojeda J. Population-Based Prevalence and Age Distribution of Human Papillomavirus Among Women in Santiago, Chile. Cancer Epidemiol Biomarkers Prev. 2004; 13: 2271-2276.
12. Faridi R, Zahra A, Khan K, Idrees M, Oncogenic potential of Human Papillomavirus (HPV) and its relation with cervical cancer. Virol J. 2011; 8(1): 269-276.
13. Martin-Hernan F, Sanchez-Hernandez J, Cano J, Campo J, del Romero J, Oral cancer, HPV infection and evidence of sexual transmission. Med Oral 2013; 18(3): 439-444.
14. Esquenazi D, Bussoloti I, Carvalho M, Barros F, The frequency of human papillomavirus findings in normal oral mucosa of healthy people by PCR. Braz J Otorhinolaryngol. 2010; 76(1): 78-84.
15. Bouda M, Gorgoulis V, Kastrinakis N, Giannoudis A, Tsoli E, Danassi-Afentaki D, Foukas P, Kyroundi A, Laskais G, Herrington S, Kittas C. “High Risk” HPV Types Are Frequently Detected in Potentially Malignant and Malignant Oral Lesions, But Not in Normal Oral Mucosa. Mod Pathol. 2000; 13(6): 644-653.
16. Flake C, Arafa J, Hall A, Ence E, Howard K, Kingsley K. Screening and detection of human papillomavirus (HPV) high-risk strains HPV16 and HPV18 in saliva samples from subjects under 18 years old in Nevada: a pilot study. BMC Oral Health 2012; 12(1): 43-51.
17. Turner D, William S, Bullen R, Catmull J, Falk J, Martin D, Mauer J, Barber A, Wang R, Gerstenberger S, Kingley K, High-risk human papillomavirus (HPV) screening and detection in healthy patient saliva samples: a pilot study. BMC Oral Health 2011; 11(1): 28-35.
18. Sánchez L, Díaz C, Martinez A. Detection of Human Papilloma Virus (HPV) in oral mucosa of women with cervical lesions and their relation to oral sex practices. Infect Agents Cancer 2010;5(1):25.
19. Pintos J, Black M, Sadeghi N, Ghadirian P, Zeitouni A, Viscidi R, Herrero R, Coutlée F, Franco E. Human papillomavirus infection and oral cancer: A case-control study in Montreal, Canada. Oral Oncol. 2008; 44(3): 242-250.
20. Pluvio J, Coronado P, Fasero M, Ramírez M, Arab C, Bellón del Amo M, García J, Vidart J. La inmunosupresión es un factor mayor de riesgo en la recidiva de las lesiones del tracto genital inferior asociadas al virus del papiloma humano. Progr Obstet Ginecol. 2010; 53(5): 179-188.
21. Ríos M, Soto A, Piña P. Epigenetic alterations in cervical cancer progresión. Rev Med Inst Mex Seguro Soc. 2015; 53(2): 212-217.
Published
2015-12-15
How to Cite
AGUIRRE, Rocío et al. Prevalence and risk factors for HPV infection in normal oral mucosa of Chilean dentistry students.. Journal of Oral Research, [S.l.], v. 4, n. 6, p. 393-398, dec. 2015. ISSN 0719-2479. Available at: <https://www.joralres.com/index.php/JOralRes/article/view/joralres.2015.075>. Date accessed: 28 apr. 2024. doi: https://doi.org/10.17126/joralres.2015.075.
Citation Formats
Issue
Vol 4 No 6
Section
Articles

Keywords

Oral cavity; oral mucosa; PCR; HPV16; HPV18.

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