Analgesic effectiveness of prophylactic therapy and continued therapy with naproxen sodium post simple extraction.
Abstract
Objective: To compare the effectiveness of prophylactic therapy and continued therapy with naproxen sodium post simple extraction. Material and methods: Prospective randomized, parallel, single-blind clinical assay, was developed in the Clínica Estomatológica of Universidad Alas Peruanas Filial Trujillo (Peru). Patients who required a simple extraction by dental caries, were randomized into three groups: 30 received naproxen sodium 550 mg preoperatively and then every 12 hours, 30 received naproxen sodium 550 mg postoperatively and then every 12 hours, and 30, ibuprofen (control group) 400 mg postoperatively and then every 8 hours, according to the established criteria. The procedure was standardized and the analgesic efficacy assessed by visual analog scale, and the presence of adverse drug reactions. Data were analyzed by IBM SPSS Statistics 22, using ANOVA and Duncan test, considering a significance level of 5%. Result: continued therapy with naproxen sodium showed higher analgesic effectiveness at 1, 8 and 24 hours (p<0,05) post simple extraction. Conclusion: continued therapy with naproxen sodium showed greater effectiveness than prophylactic therapy post simple extraction.References
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2. Ginestal E, Aguirre JM. Introducción al dolor orofacial. En: Ginestal E, Aguirre JM. Manual básico del dolor orofacial en odontología. Barcelona: Ergon; 2012.p.1-5.
3. Nagi R, Yashoda BK, Rakesh N, Reddy SS, Patil DJ. Clinical implications of prescribing nonsteroidal anti-inflammatory drugs in oral health care – A review. Oral Surg Oral Med Oral Pathol Oral Radiol. 2014. In press.
4. Shah R, Mahajan A, Shah N, Dadhania AP. Preemptive analgesia in third molar impaction surgery. Natl J Maxillofac Surg. 2012; 3(2): 144–7.
5. Moore RA, Derry S, McQuay HJ, Wiffen PJ. Single dose oral analgesics for acute postoperative pain in adults. Cochrane Database Syst Rev. 2011; 9: CD008659.
6. Crawford FI, Armstrong D, Boardman C, Coulthard P. Reducing postoperative pain by changing the process. Br J Oral Maxillofac Surg. 2011; 49(6): 459–63.
7. Yamashita Y, Sano N, Shimohira D, Danjo A, Goto M. A parallel-group comparison study of celecoxib with loxoprofen sodium in third mandibular molar extraction patients. Int J Oral Maxillofac Surg. 2014; 43(12): 1509–13.
8. Lustenberger FD, Grätz KW, Mutzbauer TS. Efficacy of ibuprofen versus lornoxicam after third molar surgery: a randomized, double-blind, crossover pilot study. Oral Maxillofac Surg. 2011;15(1):57-62.
9. Casariego Z, Jotko C. Farmacología razonada para odontólogos. Buenos Aires: Librería Akadia Editorial; 2013
10. Weinberg M, Froum SJ. Fármacos en odontología: guía de prescripción. México D.F: Editorial El Manual Moderno; 2014.
11. Sevelius H, Runkel R, Segre E, Bloomfield SS. Bioavailability of naproxen sodium and its relationship to clinical analgesic effects. Br J Clin Pharmac. 1980; 10(3): 259-63.
12. Aravena P, Benso B, Bertín A, Aravena-Torres R. Efectividad de la profilaxis analgésica con clonixinato de lisina en exodoncias: ensayo clínico aleatorio. J Oral Res 2013; 2(3): 125-30.
13. Ginestal E, Meana JJ. Farmacología del dolor orofacial. En: Ginestal E, Aguirre JM. Manual básico del dolor orofacial en odontología. Barcelona: Ergon; 2012.p.79-86.
14. Pérez H. Farmacología y terapéutica odontológica. 2da ed. Bogotá: AMOLCA; 2005
15. Bauer HC, Duarte FL, Horliana AC, Tortamano IP, Perez FE, Simone JL, Jorge WA. Assessment of preemptive analgesia with ibuprofen coadministered or not with dexamethasone in third molar surgery: a randomized double-blind controlled clinical trial. Oral Maxillofac Surg. 2013; 17(3):165–71.
16. Joshi A, Snowdon A, Rood J, Worthington H. Pain control after routine dento-alveolar day surgery: a patient satisfaction survey. Br Dent J. 2000; 189 (8): 439-42.
17. Isik K, Unsal A, Kalayci A, Durmus E, Turkey A, Turkey K. Comparison of three pain scales after impacted third molar surgery. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2011; 112(6):715-8.
18. Mehlisch D, Aspley S, Daniels SE, Southerden KA, Christensen KS. A single-tablet fixed-dose combination of racemic ibuprofen/paracetamol in the management of moderate to severe postoperative dental pain in adult and adolescent patients: a multicenter, two-stage, randomized, double-blind, parallel-group, placebo-controlled, factorial study. Clin Ther. 2010; 32(6):1033-49.
19. Savage M, Henry M. Preoperative nonsteroidal anti-inflammatory agents: review of the literature. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2004; 98(2):146-52.
20. Dias E. Prevención y control del dolor. En: Dias E. Terapéutica medicamentosa en odontología. 2da ed. Sao Paulo: Artes Médicas Latinoamérica; 2006.p.47-59
Published
2015-02-01
How to Cite
ASMAT-ABANTO, Angel Steven et al.
Analgesic effectiveness of prophylactic therapy and continued therapy with naproxen sodium post simple extraction..
Journal of Oral Research, [S.l.], v. 4, n. 1, p. 44-50, feb. 2015.
ISSN 0719-2479.
Available at: <https://www.joralres.com/index.php/JOralRes/article/view/joralres.2015.010>. Date accessed: 29 apr. 2024.
doi: https://doi.org/10.17126/joralres.2015.010.
Issue
Section
Articles
Keywords
Analgesics; naproxen; tooth extraction.
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