Exposure to endocrine disruptors and alterations in mineralized tissues: A Narrative Review.
Abstract
Background: Endocrine Disrupting Chemicals (EDCs) would cause alterations in organs/systems of exposed individuals or their progeny.
Objetive: To identify and analyze the main published findings on the effects of exposure to EDCs on teeth, cartilage, and bone.
Material and Methods: Two databases were analyzed: Medline and Web of Science. Only observational studies analyzing the effect of EDCs on mineralized tissues published since 2006 were included in the study.
Results: 25 articles were selected, most of them involving EDCs pesticides, plasticizers, or personal care products, highlighting organochlorine compounds, bisphenols, phthalates, dioxins, parabens, and perfluoroalkyls. Thirty-six per cent of the studies reported an accumulation of EDCs in teeth or bones, while 64% reported alterations in their development or morphology, mainly at the bone level, primarily affecting their mineral density and size, as well as that of the bones of exposed individuals or their progeny. The type of effect observed was related to the EDCs analyzed, and it seemed to depend on variables such as age, sex, ethnicity/race, and even the metabolic status of the individuals in the different species analyzed. No evidence associated with effects on cartilage was found.
Conclusion: EDCs in the environment, at work, or at home, under different exposure routes, are capable of accumulating in teeth and bone, particularly affecting the latter. It is necessary to study the effect of EDCs on mineralized tissues in agro-industrial areas, especially on teeth.
References
[1]. Monneret C. What is an endocrine disruptor? Endocr Disruptors Perturbateurs Endocriniens. 2017;340(9):403-5.
[2]. Kortenkamp A, Martin O, Faust M, Evans R, McKinley R, Orton F, et al. State of the art assessment of endocrine disruptors. Final Rep. 2011;2011:1-135.
[3]. Silva M. Silva, M.H., Gammon, D., 2009. An assessment of developmental, reproductive and neurobehavioral toxicology of endosulfan. Birth Defects Research: Part B. 86(1), 1-28. Birth Defects Res B Dev Reprod Toxicol. 2009;86:1-28.
[4]. Poimenova A, Markaki E, Rahiotis C, Kitraki E. Corticosterone-regulated actions in the rat brain are affected by perinatal exposure to low dose of bisphenol A. Neuroscience. 2010;167(3):741-9.
[5]. Braniste V, Jouault A, Gaultier E, Polizzi A, Buisson-Brenac C, Leveque M, et al. Impact of oral bisphenol A at reference doses on intestinal barrier function and sex differences after perinatal exposure in rats. Proc Natl Acad Sci U S A. 2010;107(1):448-53.
[6]. Menard S, Guzylack-Piriou L, Leveque M, Braniste V, Lencina C, Naturel M, Moussa L, Sekkal S, Harkat C, Gaultier E, Theodorou V, Houdeau E. Food intolerance at adulthood after perinatal exposure to the endocrine disruptor bisphenol A. FASEB J. 2014;28(11):4893-900. doi: 10.1096/fj.14-255380. Epub 2014 Aug 1. PMID: 25085925.
[7]. Haeno S, Maeda N, Yagi T, Tahata S, Sato M, Sakaguchi K, Miyasho T, Ueda H, Yokota H. Diethylstilbestrol decreased adrenal cholesterol and corticosterone in rats. J Endocrinol. 2014;221(2):261-72. doi: 10.1530/JOE-13-0460. PMID: 24578295.
[8]. Tavares RS, Escada-Rebelo S, Correia M, Mota PC, Ramalho-Santos J. The non-genomic effects of endocrine-disrupting chemicals on mammalian sperm. Reprod Camb Engl. 2016;151(1):R1-13.
[9]. Vom Saal FS, Nagel SC, Coe BL, Angle BM, Taylor JA. The estrogenic endocrine disrupting chemical bisphenol A (BPA) and obesity. Mol Cell Endocrinol. 2012;354(1-2):74-84.
[10]. Kabir ER, Rahman MS, Rahman I. A review on endocrine disruptors and their possible impacts on human health. Environ Toxicol Pharmacol. 2015;40(1):241-58.
[11]. Manterola C, Otzen T. Estudios Observacionales: Los Diseños Utilizados con Mayor Frecuencia en Investigación Clínica. Int J Morphol. 2014;32:634-45.
[12]. Muñoz Q MT, Iglesias Á VP, Lucero M BA. Exposición a organofosforados y desempeño cognitivo en escolares rurales chilenos: un estudio exploratorio. Rev Fac Nac Salud Pública. 2011;29:256-63.
[13]. Muñoz-Quezada MT, Lucero BA, Gutiérrez-Jara JP, Buralli RJ, Zúñiga-Venegas L, Muñoz MP, Ponce KV, Iglesias V. Longitudinal exposure to pyrethroids (3-PBA and trans-DCCA) and 2,4-D herbicide in rural schoolchildren of Maule region, Chile. Sci Total Environ. 2020;749:141512. doi: 10.1016/j.scitotenv.2020.141512. Epub 2020 Aug 4. PMID: 32846350.
[14]. Mora AM, Arora M, Harley KG, Kogut K, Parra K, Hernández-Bonilla D, Gunier RB, Bradman A, Smith DR, Eskenazi B. Prenatal and postnatal manganese teeth levels and neurodevelopment at 7, 9, and 10.5 years in the CHAMACOS cohort. Environ Int. 2015;84:39-54. doi: 10.1016/j.envint.2015.07.009. Epub 2015 Jul 24. PMID: 26209874; PMCID: PMC4570875.
[15]. Muñoz-Quezada MT, Lucero BA, Iglesias VP, Muñoz MP, Cornejo CA, Achu E, Baumert B, Hanchey A, Concha C, Brito AM, Villalobos M. Chronic exposure to organophosphate (OP) pesticides and neuropsychological functioning in farm workers: a review. Int J Occup Environ Health. 2016;22(1):68-79. doi: 10.1080/10773525.2015.1123848. Epub 2016 Apr 29. PMID: 27128815; PMCID: PMC4894272.
[16]. Krieter DH, Canaud B, Lemke HD, Rodriguez A, Morgenroth A, von Appen K, Dragoun GP, Wanner C. Bisphenol A in chronic kidney disease. Artif Organs. 2013;37(3):283-90. doi: 10.1111/j.1525-1594.2012.01556.x. Epub 2012 Nov 12. PMID: 23145999.
[17]. Zhang J, Liu XF, Liu Y, Xu LZ, Zhou LL, Tang LL, Zhuang J, Li TT, Guo WQ, Hu R, Qiu DS, Han DW. Environmental risk factors for women with polycystic ovary syndrome in china: a population-based case-control study. J Biol Regul Homeost Agents. 2014;28(2):203-11. PMID: 25001653.
[18]. Cardenas A, Hivert MF, Gold DR, Hauser R, Kleinman KP, Lin PD, Fleisch AF, Calafat AM, Ye X, Webster TF, Horton ES, Oken E. Associations of Perfluoroalkyl and Polyfluoroalkyl Substances With Incident Diabetes and Microvascular Disease. Diabetes Care. 2019;42(9):1824-1832. doi: 10.2337/dc18-2254. Epub 2019 Jul 11. PMID: 31296647; PMCID: PMC6702604.
[19]. Cardenas A, Hauser R, Gold DR, Kleinman KP, Hivert MF, Fleisch AF, et al. Association of Perfluoroalkyl and Polyfluoroalkyl Substances With Adiposity. JAMA Netw Open. 2018;1(4):e181493.
[20]. Rojas A, Ojeda ME, Barraza X. [Congenital malformations and pesticide exposure]. Rev Med Chil. 2000;128(4):399-404.
[21]. MacNeil RL, Somerman MJ. Development and regene-ration of the periodontium: parallels and contrasts. Periodontol 2000. 1999;19:8-20.
[22]. Thesleff I. The genetic basis of tooth development and dental defects. Am J Med Genet A. 2006;140(23):2530-5.
[23]. Yuan Y, Chai Y. Regulatory mechanisms of jaw bone and tooth development. Curr Top Dev Biol. 2019. 2019;133:91-118.
[24]. Windahl SH, Andersson G, Gustafsson JA. Elucidation of estrogen receptor function in bone with the use of mouse models. Trends Endocrinol Metab TEM. 2002;13(5):195-200.
[25]. Cangussu MCT, Narvai PC, Castellanos Fernandez R, Djehizian V. [Dental fluorosis in Brazil: a critical review]. Cad Saude Publica. 2002;18(1):7-15.
[26]. Kellerhoff NM, Lussi A. ["Molar-incisor hypomineralization"]. Schweiz Monatsschrift Zahnmed Rev Mens Suisse Odonto-Stomatol Riv Mens Svizzera Odontol E Stomatol. 2004;114(3):243-53.
[27]. Suzuki N, Hattori A. Bisphenol A suppresses osteoclastic and osteoblastic activities in the cultured scales of goldfish. Life Sci. 2003;73(17):2237-47.
[28]. Rath NC, Richards MP, Huff WE, Huff GR, Balog JM. Changes in the tibial growth plates of chickens with thiram-induced dyschondroplasia. J Comp Pathol. 2005;133(1):41-52.
[29]. Hwang YH, Son YJ, Paik MJ, Yee ST. Effects of diisononyl phthalate on osteopenia in intact mice. Toxicol Appl Pharmacol. 2017;334:120-8.
[30]. Welshons WV, Nagel SC, vom Saal FS. Large effects from small exposures. III. Endocrine mechanisms mediating effects of bisphenol A at levels of human exposure. Endocrinology. 2006;147(6 Suppl):S56-69.
[31]. Smith EP, Boyd J, Frank GR, Takahashi H, Cohen RM, Specker B, et al. Estrogen resistance caused by a mutation in the estrogen-receptor gene in a man. N Engl J Med. 1994;331(16):1056-61.
[32]. Sabbieti MG, Agas D, Palermo F, Mosconi G, Santoni G, Amantini C, Farfariello V, Marchetti L. 4-nonylphenol triggers apoptosis and affects 17-β-estradiol receptors in calvarial osteoblasts. Toxicology. 2011;290(2-3):334-41. doi: 10.1016/j.tox.2011.10.014. Epub 2011 Oct 25. PMID: 22056370.
[33]. Holz JD, Sheu T jen, Drissi H, Matsuzawa M, Zuscik MJ, Puzas JE. Environmental agents affect skeletal growth and development. Birth Defects Res Part C Embryo Today Rev. 2007;81(1):41-50.
[34]. Jedeon K, De la Dure-Molla M, Brookes SJ, Loiodice S, Marciano C, Kirkham J, Canivenc-Lavier MC, Boudalia S, Bergès R, Harada H, Berdal A, Babajko S. Enamel defects reflect perinatal exposure to bisphenol A. Am J Pathol. 2013;183(1):108-18. doi: 10.1016/j.ajpath.2013.04.004. Epub 2013 Jun 10. PMID: 23764278; PMCID: PMC3703547.
[35]. Moher D, Shamseer L, Clarke M, Ghersi D, Liberati A, Petticrew M, Shekelle P, Stewart LA; PRISMA-P Group. Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015 statement. Syst Rev. 2015;4(1):1. doi: 10.1186/2046-4053-4-1. PMID: 25554246; PMCID: PMC4320440.
[36]. Arora M, Bradman A, Austin C, Vedar M, Holland N, Eskenazi B, Smith DR. Determining fetal manganese exposure from mantle dentine of deciduous teeth. Environ Sci Technol. 2012;46(9):5118-25. doi: 10.1021/es203569f. Epub 2012 Apr 11. PMID: 22455722; PMCID: PMC3341525.
[37]. Gunier RB, Bradman A, Jerrett M, Smith DR, Harley KG, Austin C, Vedar M, Arora M, Eskenazi B. Determinants of manganese in prenatal dentin of shed teeth from CHAMACOS children living in an agricultural community. Environ Sci Technol. 2013;47(19):11249-57. doi: 10.1021/es4018688. Epub 2013 Sep 23. PMID: 24053404; PMCID: PMC4167759.
[38]. Gunier RB, Arora M, Jerrett M, Bradman A, Harley KG, Mora AM, Kogut K, Hubbard A, Austin C, Holland N, Eskenazi B. Manganese in teeth and neurodevelopment in young Mexican-American children. Environ Res. 2015 Oct;142:688-95. doi: 10.1016/j.envres.2015.09.003. PMID: 26381693; PMCID: PMC4696558.
[39]. Wang Y, Zhu H, Kannan K. A Review of Biomonitoring of Phthalate Exposures. Toxics. 5 de abril de 2019;7(2).
[40]. Lozowicka B. Health risk for children and adults consuming apples with pesticide residue. Sci Total Environ. 2015;502:184-98. doi: 10.1016/j.scitotenv.2014.09.026. Epub 2014 Sep 26. PMID: 25260164.
[41]. Camann DE, Schultz ST, Yau AY, Heilbrun LP, Zuniga MM, Palmer RF, Miller CS. Acetaminophen, pesticide, and diethylhexyl phthalate metabolites, anandamide, and fatty acids in deciduous molars: potential biomarkers of perinatal exposure. J Expo Sci Environ Epidemiol. 2013;23(2):190-6. doi: 10.1038/jes.2012.71. Epub 2012 Jul 18. PMID: 22805989.
[42]. Hassan AA, Rylander C, Brustad M, Sandanger TM. Persistent organic pollutants in meat, liver, tallow and bone marrow from semi-domesticated reindeer (Rangifer tarandus tarandus L.) in Northern Norway. Acta Vet Scand. 2013;55(1):57. doi: 10.1186/1751-0147-55-57. PMID: 23938064; PMCID: PMC3751901.
[43]. Daugaard-Petersen T, Langebæk R, Rigét FF, Dyck M, Letcher RJ, Hyldstrup L, Jensen JB, Dietz R, Sonne C. Persistent organic pollutants and penile bone mineral density in East Greenland and Canadian polar bears (Ursus maritimus) during 1996-2015. Environ Int. 2018;114:212-218. doi: 10.1016/j.envint.2018.02.022. Epub 2018 Mar 6. PMID: 29522985.
[44]. Erickson MD, Kaley RG 2nd. Applications of polychlorinated biphenyls. Environ Sci Pollut Res Int. 2011;18(2):135-51. doi: 10.1007/s11356-010-0392-1. Epub 2010 Sep 17. PMID: 20848233.
[45]. McGrath TJ, Ball AS, Clarke BO. Critical review of soil contamination by polybrominated diphenyl ethers (PBDEs) and novel brominated flame retardants (NBFRs); concentrations, sources and congener profiles. Environ Pollut. 2017;230:741-757. doi: 10.1016/j.envpol.2017.07.009. Epub 2017 Jul 18. PMID: 28732337.
[46]. Baxter CE, Pappas S, Abel MT, Kendall RJ. Organochlorine pesticides, lead, and mercury in northern bobwhite (Colinus virginianus) and scaled quail (Callipepla squa-mata) from the Rolling Plains ecoregion of Texas and Oklahoma. Environ Toxicol Chem. 2015;34(7):1505-10. doi: 10.1002/etc.2917. Epub 2015 Apr 30. PMID: 25663380.
[47]. Uhl SA, James-Todd T, Bell ML. Association of Osteoarthritis with Perfluorooctanoate and Perfluorooctane Sulfonate in NHANES 2003-2008. Environ Health Perspect. 2013;121(4):447-52. doi: 10.1289/ehp.1205673. Epub 2013 Feb 14. PMID: 23410534; PMCID: PMC3620767.
[48]. Pérez F, Nadal M, Navarro-Ortega A, Fàbrega F, Domingo JL, Barceló D, Farré M. Accumulation of perfluoroalkyl substances in human tissues. Environ Int. 2013;59:354-62. doi: 10.1016/j.envint.2013.06.004. Epub 2013 Jul 25. PMID: 23892228.
[49]. Lin LY, Wen LL, Su TC, Chen PC, Lin CY. Negative association between serum perfluorooctane sulfate concentration and bone mineral density in US premenopausal women: NHANES, 2005-2008. J Clin Endocrinol Metab. 2014;99(6):2173-80. doi: 10.1210/jc.2013-3409. Epub 2014 Feb 28. PMID: 24606077.
[50]. Koskela A, Koponen J, Lehenkari P, Viluksela M, Korkalainen M, Tuukkanen J. Perfluoroalkyl substances in human bone: concentrations in bones and effects on bone cell differentiation. Sci Rep. 2017;7(1):6841.
[51]. Authority EFS. Perfluoroalkylated substances in food: occurrence and dietary exposure. EFSA J. 2012;10(6):2743.
[52]. Buck RC, Franklin J, Berger U, Conder JM, Cousins IT, de Voogt P, Jensen AA, Kannan K, Mabury SA, van Leeuwen SP. Perfluoroalkyl and polyfluoroalkyl substances in the environment: terminology, classification, and origins. Integr Environ Assess Manag. 2011;7(4):513-41. doi: 10.1002/ieam.258. PMID: 21793199; PMCID: PMC3214619.
[53]. Khalil N, Chen A, Lee M, Czerwinski SA, Ebert JR, DeWitt JC, Kannan K. Association of Perfluoroalkyl Substances, Bone Mineral Density, and Osteoporosis in the U.S. Population in NHANES 2009-2010. Environ Health Perspect. 2016;124(1):81-7. doi: 10.1289/ehp.1307909. Epub 2015 Jun 9. PMID: 26058082; PMCID: PMC4710590.
[54]. Spear PA, Boily M, Giroux I, Deblois C, Leclair MH, Levasseur M, Leclair R. Study design, water quality, morphometrics and age of the bullfrog, Rana catesbeiana, in sub-watersheds of the Yamaska River drainage basin, Québec, Canada. Aquat Toxicol. 2009;91(2):110-7. doi: 10.1016/j.aquatox.2008.09.011. Epub 2008 Oct 1. PMID: 19027968.
[55]. Roos A, Rigét F, Orberg J. Bone mineral density in Swedish otters (Lutra lutra) in relation to PCB and DDE concentrations. Ecotoxicol Environ Saf. 2010;73(5): 1063-70.
[56]. Sonne C, Dyck M, Rigét FF, Beck Jensen JE, Hyldstrup L, Letcher RJ, Gustavson K, Gilbert MT, Dietz R. Penile density and globally used chemicals in Canadian and Greenland polar bears. Environ Res. 2015;137:287-91. doi: 10.1016/j.envres.2014.12.026. Epub 2015 Jan 16. PMID: 25601730.
[57]. Khalil N, Ebert JR, Honda M, Lee M, Nahhas RW, Koskela A, Hangartner T, Kannan K. Perfluoroalkyl substances, bone density, and cardio-metabolic risk factors in obese 8-12 year old children: A pilot study. Environ Res. 2018;160:314-321. doi: 10.1016/j.envres.2017.10.014. Epub 2017 Oct 15. PMID: 29040951.
[58]. Starek-Świechowicz B, Budziszewska B, Starek A. Hexa-chlorobenzene as a persistent organic pollutant: Toxicity and molecular mechanism of action. Pharmacol Rep PR. 2017;69(6):1232-9.
[59]. Côté S, Ayotte P, Dodin S, Blanchet C, Mulvad G, Petersen HS, Gingras S, Dewailly E. Plasma organo-chlorine concentrations and bone ultrasound mea-surements: a cross-sectional study in peri-and post-menopausal Inuit women from Greenland. Environ Health. 2006;5:33. doi: 10.1186/1476-069X-5-33. PMID: 17184534; PMCID: PMC1770911.
[60]. Olea N, Pulgar R, Pérez P, Olea-Serrano F, Rivas A, Novillo-Fertrell A, Pedraza V, Soto AM, Sonnenschein C. Estrogenicity of resin-based composites and sealants used in dentistry. Environ Health Perspect. 1996;104(3):298-305. doi: 10.1289/ehp.96104298. PMID: 8919768; PMCID: PMC1469315.
[61]. Krishnan AV, Stathis P, Permuth SF, Tokes L, Feldman D. Bisphenol-A: an estrogenic substance is released from polycarbonate flasks during autoclaving. Endocrinology. 1993;132(6):2279-86.
[62]. Biedermann S, Tschudin P, Grob K. Transfer of bisphenol A from thermal printer paper to the skin. Anal Bioanal Chem. 2010;398(1):571-6.
[63]. Vitku J, Kolatorova L, Franekova L, Blahos J, Simkova M, Duskova M, Skodova T, Starka L. Endocrine disruptors of the bisphenol and paraben families and bone metabolism. Physiol Res. 2018;67(Suppl 3):S455-S464. doi: 10.33549/physiolres.934005. PMID: 30484672.
[64]. DeFlorio-Barker SA, Turyk ME. Associations between bone mineral density and urinary phthalate metabolites among post-menopausal women: a cross-sectional study of NHANES data 2005-2010. Int J Environ Health Res. 2016;26(3):326-45. doi: 10.1080/09603123.2015.1111312. Epub 2015 Nov 20. PMID: 26586408.
[65]. Jeddy Z, Tobias JH, Taylor EV, Northstone K, Flanders WD, Hartman TJ. Prenatal concentrations of perfluoroalkyl substances and bone health in British girls at age 17. Arch Osteoporos. 2018;13(1):84.
[66]. Di Nisio A, De Rocco Ponce M, Giadone A, Rocca MS, Guidolin D, Foresta C. Perfluoroalkyl substances and bone health in young men: a pilot study. Endocrine. 2020;67(3):678-84.
[67]. Wang N, Wang Y, Zhang H, Guo Y, Chen C, Zhang W, Wan H, Han J, Lu Y. Association of bone mineral density with nine urinary personal care and consumer product chemicals and metabolites: A national-representative, population-based study. Environ Int. 2020;142:105865. doi: 10.1016/j.envint.2020.105865. Epub 2020 Jun 22. PMID: 32585503.
[68]. van Zwol-Janssens C, Trasande L, Asimakopoulos AG, Martinez-Moral MP, Kannan K, Philips EM, Rivadeneira F, Jaddoe VWV, Santos S. Fetal exposure to bisphenols and phthalates and childhood bone mass: a population-based prospective cohort study. Environ Res. 2020;186:109602. doi: 10.1016/j.envres.2020.109602. Epub 2020 May 1. PMID: 32668547; PMCID: PMC8336628.
[69]. Guo Y, Wang L, Kannan K. Phthalates and parabens in personal care products from China: concentrations and human exposure. Arch Environ Contam Toxicol. 2014;66(1):113-9.
[70]. Luo H, Sun G, Shi Y, Shen Y, Xu K. Evaluation of the Di(2-ethylhexyl) phthalate released from polyvinyl chloride medical devices that contact blood. Springer Plus. 2014; 3:58-58.
[71]. David RM, McKee RH, Butala JH, Barter RA, Kayser M. Esters of Aromatic Mono-, Di-, and Tricarboxylic Acids, Aromatic Diacids and Di-, Tri-, Or Polyalcohols. En: Patty’s Toxicology [Internet]. American Cancer Society; 2001.
[72]. Buck Louis GM, Zhai S, Smarr MM, Grewal J, Zhang C, Grantz KL, Hinkle SN, Sundaram R, Lee S, Honda M, Oh J, Kannan K. Endocrine disruptors and neonatal anthropometry, NICHD Fetal Growth Studies - Singletons. Environ Int. 2018;119:515-526. doi: 10.1016/j.envint.2018.07.024. Epub 2018 Jul 26. PMID: 30055518; PMCID: PMC6267852.
[73]. Shiue I. Urinary heavy metals, phthalates, phenols, thiocyanate, parabens, pesticides, polyaromatic hydrocarbons but not arsenic or polyfluorinated compounds are associated with adult oral health: USA NHANES, 2011-2012. Environ Sci Pollut Res Int. 2015;22(20):15636-45. doi: 10.1007/s11356-015-4749-3. Epub 2015 May 28. PMID: 26018285.
[74]. Grillo Pizarro Á, Achú Peralta E, Muñoz-Quezada MT, Lucero Mondaca B. [Exposure to organophosphate pesticides and peripheral polyneuropathy in workers from Maule Region, Chile]. Rev Esp Salud Publica. 2018;92.
[75]. Muñoz-Quezada MT, Lucero B, Iglesias V, Muñoz MP. Vías de exposición a plaguicidas en escolares de la Provincia de Talca, Chile. Gac Sanit. 2014;28(3):190-5.
[76]. Garry VF. Pesticides and children. Toxicol Appl Pharmacol. 2004;198(2):152-63.
[77]. Mie A, Rudén C, Grandjean P. Safety of Safety Evaluation of Pesticides: developmental neurotoxicity of chlorpyrifos and chlorpyrifos-methyl. Environ Health Glob Access Sci Source. 2018;17(1):77.
[78]. Guo J, Zhang J, Wu C, Lv S, Lu D, Qi X, Jiang S, Feng C, Yu H, Liang W, Chang X, Zhang Y, Xu H, Cao Y, Wang G, Zhou Z. Associations of prenatal and childhood chlorpyrifos exposure with Neurodevelopment of 3-year-old children. Environ Pollut. 2019;251:538-546. doi: 10.1016/j.envpol.2019.05.040. Epub 2019 May 10. PMID: 31108286.
[79]. Tang ZR, Xu XL, Deng SL, Lian ZX, Yu K. Oestrogenic Endocrine Disruptors in the Placenta and the Fetus. Int J Mol Sci. 2020;21(4):1519.
[80]. Murphy VE, Smith R, Giles WB, Clifton VL. Endocrine regulation of human fetal growth: the role of the mother, placenta, and fetus. Endocr Rev. 2006;27(2):141-69.
[81]. Liu C, Du Y, Zhou B. Evaluation of estrogenic activities and mechanism of action of perfluorinated chemicals determined by vitellogenin induction in primary cultu-red tilapia hepatocytes. Aquat Toxicol Amst Neth. 2007; 85(4):267-77.
[82]. Hwang JK, Min KH, Choi KH, Hwang YC, Jeong IK, Ahn KJ, et al. Bisphenol A reduces differentiation and stimulates apoptosis of osteoclasts and osteoblasts. Life Sci. 2013;93(9-11):367-72.
[83]. Kim JC, Shin HC, Cha SW, Koh WS, Chung MK, Han SS. Evaluation of developmental toxicity in rats exposed to the environmental estrogen bisphenol A during pregnancy. Life Sci. 2001;69(22):2611-25.
[84]. Agas D, Sabbieti MG, Capacchietti M, Materazzi S, Menghi G, Materazzi G, Hurley MM, Marchetti L. Benzyl butyl phthalate influences actin distribution and cell proliferation in rat Py1a osteoblasts. J Cell Biochem. 2007;101(3):543-51. doi: 10.1002/jcb.21212. PMID: 17171637.
[85]. Jedeon K, Loiodice S, Marciano C, Vinel A, Canivenc Lavier MC, Berdal A, Babajko S. Estrogen and bisphenol A affect male rat enamel formation and promote ameloblast proliferation. Endocrinology. 2014;155(9):3365-75. doi: 10.12 10/en.2013-2161. Epub 2014 Jul 8. PMID: 25004094.
[86]. Jedeon K, Loiodice S, Salhi K, Le Normand M, Houari S, Chaloyard J, Berdal A, Babajko S. Androgen Receptor Involvement in Rat Amelogenesis: An Additional Way for Endocrine-Disrupting Chemicals to Affect Enamel Synthesis. Endocrinology. 2016157(11):4287-4296. doi: 10.12 10/en.2016-1342. Epub 2016 Sep 29. PMID: 27684650.
[87]. Kim MJ, Park YJ. Bisphenols and Thyroid Hormone. Endocrinol Metab Seoul Korea. 2019;34(4):340-8.
[88]. Jedeon K, Marciano C, Loiodice S, Boudalia S, Canivenc Lavier MC, Berdal A, Babajko S. Enamel hypomineralization due to endocrine disruptors. Connect Tissue Res. 2014;55 Suppl 1:43-7. doi: 10.3109/03008207.2014.923857. PMID: 25 158179.
[89]. Jedeon K, Berdal A, Babajko A. Impact of three endocrine disruptors, Bisphenol A, Genistein and Vinclozolin on female rat enamel. Bull Group Int Rech Sci Stomatol Odontol. 2016;53(1):e28.
[90]. Weerheijm KL, Jälevik B, Alaluusua S. Molar-incisor hypo-mineralisation. Caries Res. 2001;35(5):390-1.
[91]. Weerheijm KL. Molar incisor hypomineralisation (MIH). Eur J Paediatr Dent. 2003;4(3):114-20.
[92]. Weerheijm KL. Molar incisor hypomineralization (MIH): clinical presentation, aetiology and management. Dent Update. 2004;31(1):9-12.
[93]. da Costa-Silva CM, Jeremias F, de Souza JF, Cordeiro R de CL, Santos-Pinto L, Zuanon ACC. Molar incisor hypomineralization: prevalence, severity and clinical consequences in Brazilian children. Int J Paediatr Dent. 2010;20(6):426-34.
[94]. Betts KS. Perfluoroalkyl acids: what is the evidence telling us? Environ Health Perspect. 2007;115(5):A250-6.
[95]. James-Todd TM, Chiu YH, Zota AR. Racial/ethnic disparities in environmental endocrine disrupting chemicals and women’s reproductive health outcomes: epidemiological examples across the life course. Curr Epidemiol Rep. 2016;3(2):161-80.
[96]. Nelson JW, Scammell MK, Hatch EE, Webster TF. Social disparities in exposures to bisphenol A and polyfluoroalkyl chemicals: a cross-sectional study within NHANES 2003-2006. Environ Health Glob Access Sci Source. 2012;11:10.
[97]. Buck Louis GM, Grewal J, Albert PS, Sciscione A, Wing DA, Grobman WA, Newman RB, Wapner R, D'Alton ME, Skupski D, Nageotte MP, Ranzini AC, Owen J, Chien EK, Craigo S, Hediger ML, Kim S, Zhang C, Grantz KL. Racial/ethnic standards for fetal growth: the NICHD Fetal Growth Studies. Am J Obstet Gynecol. 2015;213(4):449.e1-449.e41. doi: 10.1016/j.ajog.2015.08.032. PMID: 26410205; PMCID: PMC4584427.
[98]. Kiserud T, Piaggio G, Carroli G, Widmer M, Carvalho J, Neerup Jensen L, Giordano D, Cecatti JG, Aleem HA, Talegawkar SA, Benachi A, Diemert A, Kitoto AT, Thinkhamrop J, Lumbiganon P, Tabor A, Kriplani A, Gonzalez R, Hecher K, Hanson MA, Gülmezoglu AM, Platt LD. Correction: The World Health Organization Fetal Growth Charts: A Multinational Longitudinal Study of Ultrasound Biometric Measurements and Estimated Fetal Weight. PLoS Med. 2017;14(3):e1002284. doi: 10.1371/journal.pmed.1002284. Erratum for: PLoS Med. 2017 Jan 24;14 (1):e1002220. Erratum in: PLoS Med. 2017 Apr 20;14 (4):e1002301. PMID: 28339475; PMCID: PMC5365101.
[99]. Innes KE, Ducatman AM, Luster MI, Shankar A. Association of osteoarthritis with serum levels of the environmental contaminants perfluorooctanoate and perfluorooctane sulfonate in a large Appalachian population. Am J Epidemiol. 2011;174(4):440-50.
[100]. Loffredo LF, Coden ME, Berdnikovs S. Endocrine Disruptor Bisphenol A (BPA) Triggers Systemic Para-Inflammation and is Sufficient to Induce Airway Allergic Sensitization in Mice. Nutrients. 2020;12(2):343.
[101]. Ramírez-Santana M, Farías-Gómez C, Zúñiga-Venegas L, Sandoval R, Roeleveld N, Van der Velden K, Scheepers PTJ, Pancetti F. Biomonitoring of blood cholinesterases and acylpeptide hydrolase activities in rural inhabitants exposed to pesticides in the Coquimbo Region of Chile. PLoS One. 2018;13(5):e0196084. doi: 10.1371/journal.pone. 0196084. PMID: 29718943; PMCID: PMC5931667.
[102]. Muñoz-Quezada MT, Iglesias V, Lucero B, Steenland K, Barr DB, Levy K, Ryan PB, Alvarado S, Concha C. Predictors of exposure to organophosphate pesticides in schoolchildren in the Province of Talca, Chile. Environ Int. 2012;47:28-36. doi: 10.1016/j.envint.2012.06.002. Epub 2012 Jun 23. PMID: 22732215; PMCID: PMC3408779.
[2]. Kortenkamp A, Martin O, Faust M, Evans R, McKinley R, Orton F, et al. State of the art assessment of endocrine disruptors. Final Rep. 2011;2011:1-135.
[3]. Silva M. Silva, M.H., Gammon, D., 2009. An assessment of developmental, reproductive and neurobehavioral toxicology of endosulfan. Birth Defects Research: Part B. 86(1), 1-28. Birth Defects Res B Dev Reprod Toxicol. 2009;86:1-28.
[4]. Poimenova A, Markaki E, Rahiotis C, Kitraki E. Corticosterone-regulated actions in the rat brain are affected by perinatal exposure to low dose of bisphenol A. Neuroscience. 2010;167(3):741-9.
[5]. Braniste V, Jouault A, Gaultier E, Polizzi A, Buisson-Brenac C, Leveque M, et al. Impact of oral bisphenol A at reference doses on intestinal barrier function and sex differences after perinatal exposure in rats. Proc Natl Acad Sci U S A. 2010;107(1):448-53.
[6]. Menard S, Guzylack-Piriou L, Leveque M, Braniste V, Lencina C, Naturel M, Moussa L, Sekkal S, Harkat C, Gaultier E, Theodorou V, Houdeau E. Food intolerance at adulthood after perinatal exposure to the endocrine disruptor bisphenol A. FASEB J. 2014;28(11):4893-900. doi: 10.1096/fj.14-255380. Epub 2014 Aug 1. PMID: 25085925.
[7]. Haeno S, Maeda N, Yagi T, Tahata S, Sato M, Sakaguchi K, Miyasho T, Ueda H, Yokota H. Diethylstilbestrol decreased adrenal cholesterol and corticosterone in rats. J Endocrinol. 2014;221(2):261-72. doi: 10.1530/JOE-13-0460. PMID: 24578295.
[8]. Tavares RS, Escada-Rebelo S, Correia M, Mota PC, Ramalho-Santos J. The non-genomic effects of endocrine-disrupting chemicals on mammalian sperm. Reprod Camb Engl. 2016;151(1):R1-13.
[9]. Vom Saal FS, Nagel SC, Coe BL, Angle BM, Taylor JA. The estrogenic endocrine disrupting chemical bisphenol A (BPA) and obesity. Mol Cell Endocrinol. 2012;354(1-2):74-84.
[10]. Kabir ER, Rahman MS, Rahman I. A review on endocrine disruptors and their possible impacts on human health. Environ Toxicol Pharmacol. 2015;40(1):241-58.
[11]. Manterola C, Otzen T. Estudios Observacionales: Los Diseños Utilizados con Mayor Frecuencia en Investigación Clínica. Int J Morphol. 2014;32:634-45.
[12]. Muñoz Q MT, Iglesias Á VP, Lucero M BA. Exposición a organofosforados y desempeño cognitivo en escolares rurales chilenos: un estudio exploratorio. Rev Fac Nac Salud Pública. 2011;29:256-63.
[13]. Muñoz-Quezada MT, Lucero BA, Gutiérrez-Jara JP, Buralli RJ, Zúñiga-Venegas L, Muñoz MP, Ponce KV, Iglesias V. Longitudinal exposure to pyrethroids (3-PBA and trans-DCCA) and 2,4-D herbicide in rural schoolchildren of Maule region, Chile. Sci Total Environ. 2020;749:141512. doi: 10.1016/j.scitotenv.2020.141512. Epub 2020 Aug 4. PMID: 32846350.
[14]. Mora AM, Arora M, Harley KG, Kogut K, Parra K, Hernández-Bonilla D, Gunier RB, Bradman A, Smith DR, Eskenazi B. Prenatal and postnatal manganese teeth levels and neurodevelopment at 7, 9, and 10.5 years in the CHAMACOS cohort. Environ Int. 2015;84:39-54. doi: 10.1016/j.envint.2015.07.009. Epub 2015 Jul 24. PMID: 26209874; PMCID: PMC4570875.
[15]. Muñoz-Quezada MT, Lucero BA, Iglesias VP, Muñoz MP, Cornejo CA, Achu E, Baumert B, Hanchey A, Concha C, Brito AM, Villalobos M. Chronic exposure to organophosphate (OP) pesticides and neuropsychological functioning in farm workers: a review. Int J Occup Environ Health. 2016;22(1):68-79. doi: 10.1080/10773525.2015.1123848. Epub 2016 Apr 29. PMID: 27128815; PMCID: PMC4894272.
[16]. Krieter DH, Canaud B, Lemke HD, Rodriguez A, Morgenroth A, von Appen K, Dragoun GP, Wanner C. Bisphenol A in chronic kidney disease. Artif Organs. 2013;37(3):283-90. doi: 10.1111/j.1525-1594.2012.01556.x. Epub 2012 Nov 12. PMID: 23145999.
[17]. Zhang J, Liu XF, Liu Y, Xu LZ, Zhou LL, Tang LL, Zhuang J, Li TT, Guo WQ, Hu R, Qiu DS, Han DW. Environmental risk factors for women with polycystic ovary syndrome in china: a population-based case-control study. J Biol Regul Homeost Agents. 2014;28(2):203-11. PMID: 25001653.
[18]. Cardenas A, Hivert MF, Gold DR, Hauser R, Kleinman KP, Lin PD, Fleisch AF, Calafat AM, Ye X, Webster TF, Horton ES, Oken E. Associations of Perfluoroalkyl and Polyfluoroalkyl Substances With Incident Diabetes and Microvascular Disease. Diabetes Care. 2019;42(9):1824-1832. doi: 10.2337/dc18-2254. Epub 2019 Jul 11. PMID: 31296647; PMCID: PMC6702604.
[19]. Cardenas A, Hauser R, Gold DR, Kleinman KP, Hivert MF, Fleisch AF, et al. Association of Perfluoroalkyl and Polyfluoroalkyl Substances With Adiposity. JAMA Netw Open. 2018;1(4):e181493.
[20]. Rojas A, Ojeda ME, Barraza X. [Congenital malformations and pesticide exposure]. Rev Med Chil. 2000;128(4):399-404.
[21]. MacNeil RL, Somerman MJ. Development and regene-ration of the periodontium: parallels and contrasts. Periodontol 2000. 1999;19:8-20.
[22]. Thesleff I. The genetic basis of tooth development and dental defects. Am J Med Genet A. 2006;140(23):2530-5.
[23]. Yuan Y, Chai Y. Regulatory mechanisms of jaw bone and tooth development. Curr Top Dev Biol. 2019. 2019;133:91-118.
[24]. Windahl SH, Andersson G, Gustafsson JA. Elucidation of estrogen receptor function in bone with the use of mouse models. Trends Endocrinol Metab TEM. 2002;13(5):195-200.
[25]. Cangussu MCT, Narvai PC, Castellanos Fernandez R, Djehizian V. [Dental fluorosis in Brazil: a critical review]. Cad Saude Publica. 2002;18(1):7-15.
[26]. Kellerhoff NM, Lussi A. ["Molar-incisor hypomineralization"]. Schweiz Monatsschrift Zahnmed Rev Mens Suisse Odonto-Stomatol Riv Mens Svizzera Odontol E Stomatol. 2004;114(3):243-53.
[27]. Suzuki N, Hattori A. Bisphenol A suppresses osteoclastic and osteoblastic activities in the cultured scales of goldfish. Life Sci. 2003;73(17):2237-47.
[28]. Rath NC, Richards MP, Huff WE, Huff GR, Balog JM. Changes in the tibial growth plates of chickens with thiram-induced dyschondroplasia. J Comp Pathol. 2005;133(1):41-52.
[29]. Hwang YH, Son YJ, Paik MJ, Yee ST. Effects of diisononyl phthalate on osteopenia in intact mice. Toxicol Appl Pharmacol. 2017;334:120-8.
[30]. Welshons WV, Nagel SC, vom Saal FS. Large effects from small exposures. III. Endocrine mechanisms mediating effects of bisphenol A at levels of human exposure. Endocrinology. 2006;147(6 Suppl):S56-69.
[31]. Smith EP, Boyd J, Frank GR, Takahashi H, Cohen RM, Specker B, et al. Estrogen resistance caused by a mutation in the estrogen-receptor gene in a man. N Engl J Med. 1994;331(16):1056-61.
[32]. Sabbieti MG, Agas D, Palermo F, Mosconi G, Santoni G, Amantini C, Farfariello V, Marchetti L. 4-nonylphenol triggers apoptosis and affects 17-β-estradiol receptors in calvarial osteoblasts. Toxicology. 2011;290(2-3):334-41. doi: 10.1016/j.tox.2011.10.014. Epub 2011 Oct 25. PMID: 22056370.
[33]. Holz JD, Sheu T jen, Drissi H, Matsuzawa M, Zuscik MJ, Puzas JE. Environmental agents affect skeletal growth and development. Birth Defects Res Part C Embryo Today Rev. 2007;81(1):41-50.
[34]. Jedeon K, De la Dure-Molla M, Brookes SJ, Loiodice S, Marciano C, Kirkham J, Canivenc-Lavier MC, Boudalia S, Bergès R, Harada H, Berdal A, Babajko S. Enamel defects reflect perinatal exposure to bisphenol A. Am J Pathol. 2013;183(1):108-18. doi: 10.1016/j.ajpath.2013.04.004. Epub 2013 Jun 10. PMID: 23764278; PMCID: PMC3703547.
[35]. Moher D, Shamseer L, Clarke M, Ghersi D, Liberati A, Petticrew M, Shekelle P, Stewart LA; PRISMA-P Group. Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015 statement. Syst Rev. 2015;4(1):1. doi: 10.1186/2046-4053-4-1. PMID: 25554246; PMCID: PMC4320440.
[36]. Arora M, Bradman A, Austin C, Vedar M, Holland N, Eskenazi B, Smith DR. Determining fetal manganese exposure from mantle dentine of deciduous teeth. Environ Sci Technol. 2012;46(9):5118-25. doi: 10.1021/es203569f. Epub 2012 Apr 11. PMID: 22455722; PMCID: PMC3341525.
[37]. Gunier RB, Bradman A, Jerrett M, Smith DR, Harley KG, Austin C, Vedar M, Arora M, Eskenazi B. Determinants of manganese in prenatal dentin of shed teeth from CHAMACOS children living in an agricultural community. Environ Sci Technol. 2013;47(19):11249-57. doi: 10.1021/es4018688. Epub 2013 Sep 23. PMID: 24053404; PMCID: PMC4167759.
[38]. Gunier RB, Arora M, Jerrett M, Bradman A, Harley KG, Mora AM, Kogut K, Hubbard A, Austin C, Holland N, Eskenazi B. Manganese in teeth and neurodevelopment in young Mexican-American children. Environ Res. 2015 Oct;142:688-95. doi: 10.1016/j.envres.2015.09.003. PMID: 26381693; PMCID: PMC4696558.
[39]. Wang Y, Zhu H, Kannan K. A Review of Biomonitoring of Phthalate Exposures. Toxics. 5 de abril de 2019;7(2).
[40]. Lozowicka B. Health risk for children and adults consuming apples with pesticide residue. Sci Total Environ. 2015;502:184-98. doi: 10.1016/j.scitotenv.2014.09.026. Epub 2014 Sep 26. PMID: 25260164.
[41]. Camann DE, Schultz ST, Yau AY, Heilbrun LP, Zuniga MM, Palmer RF, Miller CS. Acetaminophen, pesticide, and diethylhexyl phthalate metabolites, anandamide, and fatty acids in deciduous molars: potential biomarkers of perinatal exposure. J Expo Sci Environ Epidemiol. 2013;23(2):190-6. doi: 10.1038/jes.2012.71. Epub 2012 Jul 18. PMID: 22805989.
[42]. Hassan AA, Rylander C, Brustad M, Sandanger TM. Persistent organic pollutants in meat, liver, tallow and bone marrow from semi-domesticated reindeer (Rangifer tarandus tarandus L.) in Northern Norway. Acta Vet Scand. 2013;55(1):57. doi: 10.1186/1751-0147-55-57. PMID: 23938064; PMCID: PMC3751901.
[43]. Daugaard-Petersen T, Langebæk R, Rigét FF, Dyck M, Letcher RJ, Hyldstrup L, Jensen JB, Dietz R, Sonne C. Persistent organic pollutants and penile bone mineral density in East Greenland and Canadian polar bears (Ursus maritimus) during 1996-2015. Environ Int. 2018;114:212-218. doi: 10.1016/j.envint.2018.02.022. Epub 2018 Mar 6. PMID: 29522985.
[44]. Erickson MD, Kaley RG 2nd. Applications of polychlorinated biphenyls. Environ Sci Pollut Res Int. 2011;18(2):135-51. doi: 10.1007/s11356-010-0392-1. Epub 2010 Sep 17. PMID: 20848233.
[45]. McGrath TJ, Ball AS, Clarke BO. Critical review of soil contamination by polybrominated diphenyl ethers (PBDEs) and novel brominated flame retardants (NBFRs); concentrations, sources and congener profiles. Environ Pollut. 2017;230:741-757. doi: 10.1016/j.envpol.2017.07.009. Epub 2017 Jul 18. PMID: 28732337.
[46]. Baxter CE, Pappas S, Abel MT, Kendall RJ. Organochlorine pesticides, lead, and mercury in northern bobwhite (Colinus virginianus) and scaled quail (Callipepla squa-mata) from the Rolling Plains ecoregion of Texas and Oklahoma. Environ Toxicol Chem. 2015;34(7):1505-10. doi: 10.1002/etc.2917. Epub 2015 Apr 30. PMID: 25663380.
[47]. Uhl SA, James-Todd T, Bell ML. Association of Osteoarthritis with Perfluorooctanoate and Perfluorooctane Sulfonate in NHANES 2003-2008. Environ Health Perspect. 2013;121(4):447-52. doi: 10.1289/ehp.1205673. Epub 2013 Feb 14. PMID: 23410534; PMCID: PMC3620767.
[48]. Pérez F, Nadal M, Navarro-Ortega A, Fàbrega F, Domingo JL, Barceló D, Farré M. Accumulation of perfluoroalkyl substances in human tissues. Environ Int. 2013;59:354-62. doi: 10.1016/j.envint.2013.06.004. Epub 2013 Jul 25. PMID: 23892228.
[49]. Lin LY, Wen LL, Su TC, Chen PC, Lin CY. Negative association between serum perfluorooctane sulfate concentration and bone mineral density in US premenopausal women: NHANES, 2005-2008. J Clin Endocrinol Metab. 2014;99(6):2173-80. doi: 10.1210/jc.2013-3409. Epub 2014 Feb 28. PMID: 24606077.
[50]. Koskela A, Koponen J, Lehenkari P, Viluksela M, Korkalainen M, Tuukkanen J. Perfluoroalkyl substances in human bone: concentrations in bones and effects on bone cell differentiation. Sci Rep. 2017;7(1):6841.
[51]. Authority EFS. Perfluoroalkylated substances in food: occurrence and dietary exposure. EFSA J. 2012;10(6):2743.
[52]. Buck RC, Franklin J, Berger U, Conder JM, Cousins IT, de Voogt P, Jensen AA, Kannan K, Mabury SA, van Leeuwen SP. Perfluoroalkyl and polyfluoroalkyl substances in the environment: terminology, classification, and origins. Integr Environ Assess Manag. 2011;7(4):513-41. doi: 10.1002/ieam.258. PMID: 21793199; PMCID: PMC3214619.
[53]. Khalil N, Chen A, Lee M, Czerwinski SA, Ebert JR, DeWitt JC, Kannan K. Association of Perfluoroalkyl Substances, Bone Mineral Density, and Osteoporosis in the U.S. Population in NHANES 2009-2010. Environ Health Perspect. 2016;124(1):81-7. doi: 10.1289/ehp.1307909. Epub 2015 Jun 9. PMID: 26058082; PMCID: PMC4710590.
[54]. Spear PA, Boily M, Giroux I, Deblois C, Leclair MH, Levasseur M, Leclair R. Study design, water quality, morphometrics and age of the bullfrog, Rana catesbeiana, in sub-watersheds of the Yamaska River drainage basin, Québec, Canada. Aquat Toxicol. 2009;91(2):110-7. doi: 10.1016/j.aquatox.2008.09.011. Epub 2008 Oct 1. PMID: 19027968.
[55]. Roos A, Rigét F, Orberg J. Bone mineral density in Swedish otters (Lutra lutra) in relation to PCB and DDE concentrations. Ecotoxicol Environ Saf. 2010;73(5): 1063-70.
[56]. Sonne C, Dyck M, Rigét FF, Beck Jensen JE, Hyldstrup L, Letcher RJ, Gustavson K, Gilbert MT, Dietz R. Penile density and globally used chemicals in Canadian and Greenland polar bears. Environ Res. 2015;137:287-91. doi: 10.1016/j.envres.2014.12.026. Epub 2015 Jan 16. PMID: 25601730.
[57]. Khalil N, Ebert JR, Honda M, Lee M, Nahhas RW, Koskela A, Hangartner T, Kannan K. Perfluoroalkyl substances, bone density, and cardio-metabolic risk factors in obese 8-12 year old children: A pilot study. Environ Res. 2018;160:314-321. doi: 10.1016/j.envres.2017.10.014. Epub 2017 Oct 15. PMID: 29040951.
[58]. Starek-Świechowicz B, Budziszewska B, Starek A. Hexa-chlorobenzene as a persistent organic pollutant: Toxicity and molecular mechanism of action. Pharmacol Rep PR. 2017;69(6):1232-9.
[59]. Côté S, Ayotte P, Dodin S, Blanchet C, Mulvad G, Petersen HS, Gingras S, Dewailly E. Plasma organo-chlorine concentrations and bone ultrasound mea-surements: a cross-sectional study in peri-and post-menopausal Inuit women from Greenland. Environ Health. 2006;5:33. doi: 10.1186/1476-069X-5-33. PMID: 17184534; PMCID: PMC1770911.
[60]. Olea N, Pulgar R, Pérez P, Olea-Serrano F, Rivas A, Novillo-Fertrell A, Pedraza V, Soto AM, Sonnenschein C. Estrogenicity of resin-based composites and sealants used in dentistry. Environ Health Perspect. 1996;104(3):298-305. doi: 10.1289/ehp.96104298. PMID: 8919768; PMCID: PMC1469315.
[61]. Krishnan AV, Stathis P, Permuth SF, Tokes L, Feldman D. Bisphenol-A: an estrogenic substance is released from polycarbonate flasks during autoclaving. Endocrinology. 1993;132(6):2279-86.
[62]. Biedermann S, Tschudin P, Grob K. Transfer of bisphenol A from thermal printer paper to the skin. Anal Bioanal Chem. 2010;398(1):571-6.
[63]. Vitku J, Kolatorova L, Franekova L, Blahos J, Simkova M, Duskova M, Skodova T, Starka L. Endocrine disruptors of the bisphenol and paraben families and bone metabolism. Physiol Res. 2018;67(Suppl 3):S455-S464. doi: 10.33549/physiolres.934005. PMID: 30484672.
[64]. DeFlorio-Barker SA, Turyk ME. Associations between bone mineral density and urinary phthalate metabolites among post-menopausal women: a cross-sectional study of NHANES data 2005-2010. Int J Environ Health Res. 2016;26(3):326-45. doi: 10.1080/09603123.2015.1111312. Epub 2015 Nov 20. PMID: 26586408.
[65]. Jeddy Z, Tobias JH, Taylor EV, Northstone K, Flanders WD, Hartman TJ. Prenatal concentrations of perfluoroalkyl substances and bone health in British girls at age 17. Arch Osteoporos. 2018;13(1):84.
[66]. Di Nisio A, De Rocco Ponce M, Giadone A, Rocca MS, Guidolin D, Foresta C. Perfluoroalkyl substances and bone health in young men: a pilot study. Endocrine. 2020;67(3):678-84.
[67]. Wang N, Wang Y, Zhang H, Guo Y, Chen C, Zhang W, Wan H, Han J, Lu Y. Association of bone mineral density with nine urinary personal care and consumer product chemicals and metabolites: A national-representative, population-based study. Environ Int. 2020;142:105865. doi: 10.1016/j.envint.2020.105865. Epub 2020 Jun 22. PMID: 32585503.
[68]. van Zwol-Janssens C, Trasande L, Asimakopoulos AG, Martinez-Moral MP, Kannan K, Philips EM, Rivadeneira F, Jaddoe VWV, Santos S. Fetal exposure to bisphenols and phthalates and childhood bone mass: a population-based prospective cohort study. Environ Res. 2020;186:109602. doi: 10.1016/j.envres.2020.109602. Epub 2020 May 1. PMID: 32668547; PMCID: PMC8336628.
[69]. Guo Y, Wang L, Kannan K. Phthalates and parabens in personal care products from China: concentrations and human exposure. Arch Environ Contam Toxicol. 2014;66(1):113-9.
[70]. Luo H, Sun G, Shi Y, Shen Y, Xu K. Evaluation of the Di(2-ethylhexyl) phthalate released from polyvinyl chloride medical devices that contact blood. Springer Plus. 2014; 3:58-58.
[71]. David RM, McKee RH, Butala JH, Barter RA, Kayser M. Esters of Aromatic Mono-, Di-, and Tricarboxylic Acids, Aromatic Diacids and Di-, Tri-, Or Polyalcohols. En: Patty’s Toxicology [Internet]. American Cancer Society; 2001.
[72]. Buck Louis GM, Zhai S, Smarr MM, Grewal J, Zhang C, Grantz KL, Hinkle SN, Sundaram R, Lee S, Honda M, Oh J, Kannan K. Endocrine disruptors and neonatal anthropometry, NICHD Fetal Growth Studies - Singletons. Environ Int. 2018;119:515-526. doi: 10.1016/j.envint.2018.07.024. Epub 2018 Jul 26. PMID: 30055518; PMCID: PMC6267852.
[73]. Shiue I. Urinary heavy metals, phthalates, phenols, thiocyanate, parabens, pesticides, polyaromatic hydrocarbons but not arsenic or polyfluorinated compounds are associated with adult oral health: USA NHANES, 2011-2012. Environ Sci Pollut Res Int. 2015;22(20):15636-45. doi: 10.1007/s11356-015-4749-3. Epub 2015 May 28. PMID: 26018285.
[74]. Grillo Pizarro Á, Achú Peralta E, Muñoz-Quezada MT, Lucero Mondaca B. [Exposure to organophosphate pesticides and peripheral polyneuropathy in workers from Maule Region, Chile]. Rev Esp Salud Publica. 2018;92.
[75]. Muñoz-Quezada MT, Lucero B, Iglesias V, Muñoz MP. Vías de exposición a plaguicidas en escolares de la Provincia de Talca, Chile. Gac Sanit. 2014;28(3):190-5.
[76]. Garry VF. Pesticides and children. Toxicol Appl Pharmacol. 2004;198(2):152-63.
[77]. Mie A, Rudén C, Grandjean P. Safety of Safety Evaluation of Pesticides: developmental neurotoxicity of chlorpyrifos and chlorpyrifos-methyl. Environ Health Glob Access Sci Source. 2018;17(1):77.
[78]. Guo J, Zhang J, Wu C, Lv S, Lu D, Qi X, Jiang S, Feng C, Yu H, Liang W, Chang X, Zhang Y, Xu H, Cao Y, Wang G, Zhou Z. Associations of prenatal and childhood chlorpyrifos exposure with Neurodevelopment of 3-year-old children. Environ Pollut. 2019;251:538-546. doi: 10.1016/j.envpol.2019.05.040. Epub 2019 May 10. PMID: 31108286.
[79]. Tang ZR, Xu XL, Deng SL, Lian ZX, Yu K. Oestrogenic Endocrine Disruptors in the Placenta and the Fetus. Int J Mol Sci. 2020;21(4):1519.
[80]. Murphy VE, Smith R, Giles WB, Clifton VL. Endocrine regulation of human fetal growth: the role of the mother, placenta, and fetus. Endocr Rev. 2006;27(2):141-69.
[81]. Liu C, Du Y, Zhou B. Evaluation of estrogenic activities and mechanism of action of perfluorinated chemicals determined by vitellogenin induction in primary cultu-red tilapia hepatocytes. Aquat Toxicol Amst Neth. 2007; 85(4):267-77.
[82]. Hwang JK, Min KH, Choi KH, Hwang YC, Jeong IK, Ahn KJ, et al. Bisphenol A reduces differentiation and stimulates apoptosis of osteoclasts and osteoblasts. Life Sci. 2013;93(9-11):367-72.
[83]. Kim JC, Shin HC, Cha SW, Koh WS, Chung MK, Han SS. Evaluation of developmental toxicity in rats exposed to the environmental estrogen bisphenol A during pregnancy. Life Sci. 2001;69(22):2611-25.
[84]. Agas D, Sabbieti MG, Capacchietti M, Materazzi S, Menghi G, Materazzi G, Hurley MM, Marchetti L. Benzyl butyl phthalate influences actin distribution and cell proliferation in rat Py1a osteoblasts. J Cell Biochem. 2007;101(3):543-51. doi: 10.1002/jcb.21212. PMID: 17171637.
[85]. Jedeon K, Loiodice S, Marciano C, Vinel A, Canivenc Lavier MC, Berdal A, Babajko S. Estrogen and bisphenol A affect male rat enamel formation and promote ameloblast proliferation. Endocrinology. 2014;155(9):3365-75. doi: 10.12 10/en.2013-2161. Epub 2014 Jul 8. PMID: 25004094.
[86]. Jedeon K, Loiodice S, Salhi K, Le Normand M, Houari S, Chaloyard J, Berdal A, Babajko S. Androgen Receptor Involvement in Rat Amelogenesis: An Additional Way for Endocrine-Disrupting Chemicals to Affect Enamel Synthesis. Endocrinology. 2016157(11):4287-4296. doi: 10.12 10/en.2016-1342. Epub 2016 Sep 29. PMID: 27684650.
[87]. Kim MJ, Park YJ. Bisphenols and Thyroid Hormone. Endocrinol Metab Seoul Korea. 2019;34(4):340-8.
[88]. Jedeon K, Marciano C, Loiodice S, Boudalia S, Canivenc Lavier MC, Berdal A, Babajko S. Enamel hypomineralization due to endocrine disruptors. Connect Tissue Res. 2014;55 Suppl 1:43-7. doi: 10.3109/03008207.2014.923857. PMID: 25 158179.
[89]. Jedeon K, Berdal A, Babajko A. Impact of three endocrine disruptors, Bisphenol A, Genistein and Vinclozolin on female rat enamel. Bull Group Int Rech Sci Stomatol Odontol. 2016;53(1):e28.
[90]. Weerheijm KL, Jälevik B, Alaluusua S. Molar-incisor hypo-mineralisation. Caries Res. 2001;35(5):390-1.
[91]. Weerheijm KL. Molar incisor hypomineralisation (MIH). Eur J Paediatr Dent. 2003;4(3):114-20.
[92]. Weerheijm KL. Molar incisor hypomineralization (MIH): clinical presentation, aetiology and management. Dent Update. 2004;31(1):9-12.
[93]. da Costa-Silva CM, Jeremias F, de Souza JF, Cordeiro R de CL, Santos-Pinto L, Zuanon ACC. Molar incisor hypomineralization: prevalence, severity and clinical consequences in Brazilian children. Int J Paediatr Dent. 2010;20(6):426-34.
[94]. Betts KS. Perfluoroalkyl acids: what is the evidence telling us? Environ Health Perspect. 2007;115(5):A250-6.
[95]. James-Todd TM, Chiu YH, Zota AR. Racial/ethnic disparities in environmental endocrine disrupting chemicals and women’s reproductive health outcomes: epidemiological examples across the life course. Curr Epidemiol Rep. 2016;3(2):161-80.
[96]. Nelson JW, Scammell MK, Hatch EE, Webster TF. Social disparities in exposures to bisphenol A and polyfluoroalkyl chemicals: a cross-sectional study within NHANES 2003-2006. Environ Health Glob Access Sci Source. 2012;11:10.
[97]. Buck Louis GM, Grewal J, Albert PS, Sciscione A, Wing DA, Grobman WA, Newman RB, Wapner R, D'Alton ME, Skupski D, Nageotte MP, Ranzini AC, Owen J, Chien EK, Craigo S, Hediger ML, Kim S, Zhang C, Grantz KL. Racial/ethnic standards for fetal growth: the NICHD Fetal Growth Studies. Am J Obstet Gynecol. 2015;213(4):449.e1-449.e41. doi: 10.1016/j.ajog.2015.08.032. PMID: 26410205; PMCID: PMC4584427.
[98]. Kiserud T, Piaggio G, Carroli G, Widmer M, Carvalho J, Neerup Jensen L, Giordano D, Cecatti JG, Aleem HA, Talegawkar SA, Benachi A, Diemert A, Kitoto AT, Thinkhamrop J, Lumbiganon P, Tabor A, Kriplani A, Gonzalez R, Hecher K, Hanson MA, Gülmezoglu AM, Platt LD. Correction: The World Health Organization Fetal Growth Charts: A Multinational Longitudinal Study of Ultrasound Biometric Measurements and Estimated Fetal Weight. PLoS Med. 2017;14(3):e1002284. doi: 10.1371/journal.pmed.1002284. Erratum for: PLoS Med. 2017 Jan 24;14 (1):e1002220. Erratum in: PLoS Med. 2017 Apr 20;14 (4):e1002301. PMID: 28339475; PMCID: PMC5365101.
[99]. Innes KE, Ducatman AM, Luster MI, Shankar A. Association of osteoarthritis with serum levels of the environmental contaminants perfluorooctanoate and perfluorooctane sulfonate in a large Appalachian population. Am J Epidemiol. 2011;174(4):440-50.
[100]. Loffredo LF, Coden ME, Berdnikovs S. Endocrine Disruptor Bisphenol A (BPA) Triggers Systemic Para-Inflammation and is Sufficient to Induce Airway Allergic Sensitization in Mice. Nutrients. 2020;12(2):343.
[101]. Ramírez-Santana M, Farías-Gómez C, Zúñiga-Venegas L, Sandoval R, Roeleveld N, Van der Velden K, Scheepers PTJ, Pancetti F. Biomonitoring of blood cholinesterases and acylpeptide hydrolase activities in rural inhabitants exposed to pesticides in the Coquimbo Region of Chile. PLoS One. 2018;13(5):e0196084. doi: 10.1371/journal.pone. 0196084. PMID: 29718943; PMCID: PMC5931667.
[102]. Muñoz-Quezada MT, Iglesias V, Lucero B, Steenland K, Barr DB, Levy K, Ryan PB, Alvarado S, Concha C. Predictors of exposure to organophosphate pesticides in schoolchildren in the Province of Talca, Chile. Environ Int. 2012;47:28-36. doi: 10.1016/j.envint.2012.06.002. Epub 2012 Jun 23. PMID: 22732215; PMCID: PMC3408779.
Published
2022-10-31
How to Cite
CONTRERAS-MEZA, Paula; JACQUES, Jaime A..
Exposure to endocrine disruptors and alterations in mineralized tissues: A Narrative Review..
Journal of Oral Research, [S.l.], v. 11, n. 5, p. 1-16, oct. 2022.
ISSN 0719-2479.
Available at: <https://www.joralres.com/index.php/JOralRes/article/view/joralres.2022.060>. Date accessed: 25 apr. 2024.
doi: https://doi.org/10.17126/joralres.2022.060.
Section
Reviews
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