Prevalence of oral manifestations of hypophosphatemic rickets in patients treated in a Peruvian Pediatric Hospital.
Abstract
Objective: To describe the prevalence of oral manifestations of hypophosphatemic rickets in patients treated in a Peruvian referral pediatric hospital during the years 2012-2016. Material and methods: An observational, descriptive, retrospective, cross-sectional study was carried out. The sample consisted of patients diagnosed with hypophosphatemic rickets who attended the outpatient clinic of the Stomatology Service and the Genetics Service of the National Institute of Child Health (INSN), Lima, Peru, between the years 2012-2016. The research project was assessed and approved by the Research Ethics Committee of the Health Service. Medical records stored in a database of the health institution with the Code CIE E83.3, which corresponds to the diagnosis of Hypophosphatemic Rickets, were requested for the study. Results: Fifteen children received health care, of which only 10 were treated at the Stomatology Service. The distribution of the data was obtained from these 10 patients according to the proposed objective. A higher frequency of gingival lesions was found at the soft tissue level (41.18%); at the bone tissue level, only one case of dentigerous cyst was observed; and at the dental level, 90% of the patients had dental caries. Conclusion: The most frequent oral manifestations of hypophosphatemic rickets in pediatric patients treated at the National Institute of Child Health (2012-2016) were gingivitis and dental caries.
References
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[40]. Beltes C, Zachou E. Endodontic management in a patient with vitamin D-resistant rickets. J Endod. 2012; 38:255-258.
[41]. Lee BN, Jung HY, Chang HS, Hwang YC, Oh WM. Dental management of patients with X-linked hypophosphatemia. Restor Dent Endod. 2017;42(2):146-151.
[42]. Koehne T, Marshall RP, Jeschke A, Kahl-Nieke B, Schinke T, Amling M. Osteopetrosis, osteopetrorickets and hypophosphatemic rickets differentially affect dentin and enamel mineralization. Bone. 2013;53:25-33.
[43]. Thakur M. Familial Vitamin D-dependent rickets Type 2A: A report of two cases with alopecia and oral manifestations. J Oral Maxillofac Pathol. 2019;23(Suppl1):130-133.
[2]. Albright F, Butler AM, Bloomberg E. Rickets resistant to vitamin D therapy. Am J Dis Child. 1937;54:529–47.
[3]. Gattineni J, Baum M. Genetic disorders of phosphate regulation. Pediatr Nephrol. 2012;27:1477-87.
[4]. Stratakis CA, Mitsiades NS, Sun D, Chrousos GP, O’Connell A. Recurring oral giant cell lesion in a child with X-linked hypophosphatemic rickets: clinical manifestation of occult parathyroidism? J Pediatr. 1995;127:444–6.
[5]. Goodman JR, Gelbier MJ, Bennett JH, Winter GB. Dental problems associated with hypophosphataemic vitamin D resistant rickets. Int J Paediatr Dent. 1998;8:19–28.
[6]. Shroff D, McWhorter A. Evaluation of aggressive pulp therapy in a population of vitamin D-resistant rickets patients: a follow-up of 4 cases. Pediatr Dent. 2002; 24:347-9.
[7]. Malloy PJ, Pike JW, Feldman D. The vitamin D receptor and the syndrome of hereditary 1, 25-dihydroxyvitamin D-resistant rickets. Endocr Rev. 1999;20:156–88.
[8]. Jagtap VS, Sarathi V, Lila AR, Bandgar T, Menon P, Shah NS. Hypophosphatemic rickets. Indian J Endocrinol Metab. 2012;16(2):177-82.
[9]. De la Calle T. Raquitismo carencial. Raquitismos resis-tentes. Pediatr Integral. 2015;19(7):477-487.
[10]. Velásquez-Jones L, Medeiros-Domingo M. Raquitismos hipofosfatémicos hereditarios. Bol Med Hosp Infant Mex. 2013;70(6):421-31.
[11]. Velásquez JL. Alteraciones Hidroelectrolíticas en Pediatría. México: Editorial Prado; 2010.
[12]. Santos F, Fuente R, Mejia N, Mantecon L, Gil-Peña H, Ordoñez FA. Hypophosphatemia and growth. Pediatr Nephrol. 2013;28:595-603.
[13]. Linglart A, Biosse-Duplan M, Briot K, Chaussain C, Esterle L, Guillaume-Czitrom S, Kamenicky P, Nevoux J, Prié D, Rothenbuhler A, Wicart P, Harvengt P. Therapeutic management of hypophosphatemic rickets from infancy to adulthood. Endocr Connect. 2014;3(1):R13-30.
[14]. James M, Roudsari RV. Prosthetic rehabilitation of a patient with X-linked hypophosphatemia using dental implants: a case report and review of the literature. Int J Implant Dent. 2019;5(1):15.
[15]. Fuente R, Gil-Peña H, Claramunt-Taberner D, Hernández O, Fernández-Iglesias A, Alonso-Durán L, Rodríguez-Rubio E, Santos F. X-linked hypophosphatemia and growth. Rev Endocr Metab Disord. 2017;18(1):107-115.
[16]. Velásquez JL, Gordillo PG. Raquitismo dependiente de vitamina D tipo I: tratamiento con 1,25-dihidroxivitamina D. Bol Med Hosp Infant Mex. 1984;41:36-40.
[17]. Rothenbuhler A, Schnabel D, Högler W, Linglart A. Diagnosis, treatment-monitoring and follow-up of children and adolescents with X-linked hypophosphatemia (XLH). Metabolism. 2020;103S:153892.
[18]. Rothenbuhler A, Fadel N, Debza Y, Bacchetta J, Diallo MT, Adamsbaum C, Linglart A, Di Rocco F. High Incidence of Cranial Synostosis and Chiari I Malformation in Children With X-Linked Hypophosphatemic Rickets (XLHR). J Bone Miner Res. 2019;34(3):490-496.
[19]. Vega RA, Opalak C, Harshbarger RJ, Fearon JA, Ritter AM, Collins JJ, Rhodes JL. Hypophosphatemic rickets and craniosynostosis: a multicenter case series. J Neurosurg Pediatr. 2016;17(6):694-700.
[20]. Harris R, Sullivan HR. Dental sequelae in deciduous dentition in vitamin D resistant rickets. Aust Dent J. 1960;5:200–3.
[21]. Hanisch M, Bohner L, Sabandal MMI, Kleinheinz J, Jung S. Oral symptoms and oral health-related quality of life of individuals with x-linked hypophosphatemia. Head Face Med. 2019;15(1):8.
[22]. Batra P, Tejani Z, Mars M. X-linked hypophosphatemia: dental and histologic findings. J Can Dent Assoc. 2006;72(1):69-72.
[23]. Rabbani A, Rahmani P, Ziaee V, Ghodoosi S. Dental problems in hypophosphatemic rickets, a cross sectional study. Iran J Pediatr. 2012;22(4):531-4.
[24]. Sollecito TP, Sullivan KE, Pinto A, Stewart J, Korostoff J. Systemic conditions associated with periodontitis in childhood and adolescence. A review of diagnostic possibilities. Med Oral Patol Oral Cir Bucal. 2005 Mar-Apr;10(2):142-50.
[25]. Murayama T, Iwatsubo R, Akiyama S, Amano A, Morisaki I. Familial hypophosphatemic vitamin D-resistant rickets: dental findings and histologic study of teeth. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2000;90:310–6.
[26]. Souza MA, Soares Junior LA, Santos MA, Vaisbich MH. Dental abnormalities and oral health in patients with Hypophosphatemic rickets. Clinics (Sao Paulo). 2010;65(10):1023-6. 27. Hanna AE, Sanjad S, Andary R, Nemer G, Ghafari JG. Tooth Development Associated with Mutations in Hereditary Vitamin D–Resistant Rickets. JDR Clin Trans Res. 2018;3(1):28–34.
[28]. Ozkan S, Ucok Z, Alagol F. Dental manifestations of familial hypophosphatemic vitamin-D-resistant rickets. ASDC J Dent Child. 1984;51:448–50.
[29]. Pereira CM, de Andrade CR, Vargas PA, Coletta RD, de Almeida OP, Lopes MA. Dental alterations associated with Xlinked hypophosphatemic rickets. J Endod. 2004;30:241-245.
[30]. Yasufuku Y, Kohno N, Tsutsumi N, Ooshima T, Sobue S, Murakami Y, Ikari H Dental management of familial hypophosphatemic vitamin D-resistant rickets: report of case. ASDC J Dent Child. 1983;50(4):300–4.
[31]. Herbert FL. Hereditary hypophosphatemia rickets: an important awareness for dentists. ASDC J Dent Child. 1986;53:223–6.
[32]. Shafer W, Hine M, Levy B. Oral pathology. 3rd ed. Philadelphia: WB Saunders, 1974:593–5.
[33]. Lecoq AL, Brandi ML, Linglart A, Kamenický P. Management of X-linked hypophosphatemia in adults. Metabolism. 2020;103S:154049.
[34]. Lambert AS, Zhukouskaya V, Rothenbuhler A, Linglart A. X-linked hypophosphatemia: Management and treatment prospects. Joint Bone Spine. 2019;86(6):731-738.
[35]. Baroncelli GI, Angiolini M, Ninni E, Galli V, Saggese R, Giuca MR. Prevalence and pathogenesis of dental and periodontal lesions in children with X-linked hypophosphatemic rickets. Eur J Paediatr Dent. 2006;7(2):61-6.
[36]. Tyas MJ, Anusavice KJ, Frencken JE, Mount GJ. Minimal intervention dentistry--a review. FDI Commission Project 1-97. Int Dent J. 2000;50(1):1-12.
[37]. Featherstone JDB, Alston P, Chaffee BW, Rechmann P. Caries Management by Risk Assessment (CAMBRA): An Update for Use in Clinical Practice for Patients Aged 6 Through Adult. J Calif Dent Assoc. 2019;47(1):16-25.
[38]. Sakihara GA, Choqque TH, Mendoza BA, López CV, Pimentel KG, Encinas AM, Ancieta ZA. Raquitismo Renal Hipofosfatémico Experiencia en 10 Años. Rev Peru Pediatr. 2014;67(1):22-30.
[39]. Godina G, Belmont F. Características dentales del raquitismo hipofosfatémico. Reporte de un caso. Rev Odonto Mexic. 2013;17(2):101-8.
[40]. Beltes C, Zachou E. Endodontic management in a patient with vitamin D-resistant rickets. J Endod. 2012; 38:255-258.
[41]. Lee BN, Jung HY, Chang HS, Hwang YC, Oh WM. Dental management of patients with X-linked hypophosphatemia. Restor Dent Endod. 2017;42(2):146-151.
[42]. Koehne T, Marshall RP, Jeschke A, Kahl-Nieke B, Schinke T, Amling M. Osteopetrosis, osteopetrorickets and hypophosphatemic rickets differentially affect dentin and enamel mineralization. Bone. 2013;53:25-33.
[43]. Thakur M. Familial Vitamin D-dependent rickets Type 2A: A report of two cases with alopecia and oral manifestations. J Oral Maxillofac Pathol. 2019;23(Suppl1):130-133.
Published
2020-10-31
How to Cite
GUEVARA-CANALES, Janet Ofelia et al.
Prevalence of oral manifestations of hypophosphatemic rickets in patients treated in a Peruvian Pediatric Hospital..
Journal of Oral Research, [S.l.], v. 9, n. 5, p. 383-391, oct. 2020.
ISSN 0719-2479.
Available at: <https://www.joralres.com/index.php/JOralRes/article/view/joralres.2020.079>. Date accessed: 19 apr. 2024.
doi: https://doi.org/10.17126/joralres.2020.079.
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