Dental stem cells and their application in dentistry.
Abstract
Recent advances in tissue engineering and regenerative medicine offer a long-term solution through biological repair, replacement of damaged teeth or maintenance and improvement of tissue and organ function through the use of stem cells. Stem cells or also called universal cells, progenitor cells or precursor cells; they are primitive, undifferentiated, clonogenic cells that are characterized by their self-renewal capabilities and that can be differentiated into more specialized cells with specific functions. Currently many sources are known from where you can obtain stem cells, one of which are those obtained from oral or dental tissues, called dental stem cells (DSC), from where it has been possible to identify, isolate and characterize around 8 unique populations: dental pulp stem cells (DPSC), human exfoliated deciduous tooth stem cells (SHED), periodontal ligament stem cells (PLDSC), dental follicle stem cells (DFSC), stem cells derived from bone alveolar (CMHA), the stem cells of the apical papilla (SCAP), the stem cells of the dental germ (DGSC) and the gingival stem cells (GSC). These DSC have attracted attention in recent years due to their accessibility, plasticity and high proliferation capacity. Currently, DSC have shown that they can be used in endodontic and periodontal regenerative therapy, in the regeneration of dentin and bone and in dental bioengineering. Tissue engineering methodologies combined with a greater understanding of the biology of DSCs will provide powerful tools for a broader spectrum of their application in various future therapeutic strategies.
References
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3. Mitsiadis TA, Orsini G, Jimenez-Rojo L. Stem cell-based approaches in dentistry. Eur Cell Mater. 2015; 30: 248-57.
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5. Hu L, Liu Y, Wang S. Stem cell-based tooth and periodontal regeneration. Oral Dis. 2018; 24(5): 696-705.
6. Miran S, Mitsiadis TA, Pagella P. Innovate dental stem cell-based research approaches: The future of Dentistry. Stem Cells Int. 2016; 2016: 7231038.
7. Mao X, Liu Y, Chen C, Shi S. Mesenchymal stem cells and their role in dental medicine. Dent Clin North Am. 2017; 61(1): 161-72.
8. Asutay F, Acar HA, Yolcu U, Kirtay M, Alan H. Dental stem cell sources and their potentials for bone tissue engineering. J Istanb Univ Fac Dent. 2015; 49(2): 51-6.
9. Morsczeck C, Reichert TE. Dental stem cells in tooth regeneration and repair in the future. Expert Opin Biol Ther. 2018; 18(2): 187-96.
10. Cui D, Li H, Wan M, Peng Y, Xu X, Zhou X, Zheng L. The origin and identification of mesenchymal stem cells in teeth: from odontogenic to non-odontogenic. Curr Stem Cell Res Ther. 2018; 13(1): 39-45.
11. Zhang W, Ouyang H, Dass CR, Xu J. Current research on pharmacologic and regenerative therapies for osteoarthritis. Bone Ress. 2016; 4: 15040.
12. Chen YY, He ST, Yan FH, Zhou PF, Luo K, Zhang YD, Xiao Y, Lin MK. Dental pulp stem cells express tendon markers under mechanical loading and are a potential cell source for tissue engineering of tendon-like tissue. Int J Oral Sci. 2016; 8(4): 213-22.
13. Pilipchuk SP, Plonka AB, Monje A, Taut AD, Lanis A, Kang B, Giannobile WV. Tissue engineering for bone regeneration and osseointegration in the oral cavity. Dent Mater. 2015; 31(4): 317-38.
14. Mao AS, Mooney DJ. Regenerative medicine: current therapies and future directions. Proc Natl Acad Sci U S A. 2015; 112(47): 14452-9.
15. Bansal R, Jain A. Current overview on dental stem cells applications in regenative dentistry. J Nat Sci Biol Med. 2015; 6(1): 29-34.
16. Abdel Meguid E, Ke Y, Ji J, El-Hashash AHK. Stem cells applications in bone and tooth repair and regeneration: New insights, tools, and hopes. J Cell Physiol. 2018; 233(3): 1825-35.
17. Har A, Park JC. Dental Stem cells and their applications. Chin J Dent Res. 2015; 18(4): 207-12.
18. Baniebrahimi G, Khanmohammadi R, Mir F. Teeth-derived stem cells: A source for cell therapy. J Cell Physiol. 2019; 234(3): 2426-35.
19. Khazaei M, Bozorgi A, Khazaei S, Khademi A. Stem cells in dentistry, sources and applications. Dent Hypotheses. 2016; 7: 42-52.
20. Goradel NH, Hour FG, Negahdari B, Malekshahi ZV, Hashemzehi M, Masoudifar A, Mirzaei H. Stem cell therapy: A new therapeutic option for cardiovascular diseases. J Cell Biochem. 2018; 119(1): 95-104.
21. Mirzaei H, Sahebkar A, Avan A, Jaafari MR, Salehi R, Salehi H, Baharvand H, Rezaei A, Hadjati J, Pawelek JM, Mirzaei HR. Application of mesenchymal stem cells in melanoma: A potential therapeutic strategy for delivery of targeted agents. Curr Med Chem. 2016; 23(5): 455-63.
22. Mohammadi M, Jaafari MR, Mirzaei HR, Mirzaei H. Mesenchymal stem cell: A new horizon in cancer gene therapy. Cancer Gene Ther. 2016; 23(9): 285-6.
23. Mirzaei H, Sahebkar A, Sichani LS, Moridikia A, Nazari S, Sadri Nahand J, Salehi H, Stenvang J, Masoudifar A, Mirzaei HR, Jaafari MR. Therapeutic application of multipotent stem cells. J Cell Physiol. 2018; 233(4): 2815-23.
24. Mirzaei H, Salehi H, Oskuee RK, Mohammadpour A, Mirzaei HR, Sharifi MR, Salarinia R, Darani HY, Mokhtari M, Masoudifar A, Sahebkar A, Salehi R, Jaafari MR. The therapeutic potential of human adipose-derived mesenchymal stem cells producing CXCL 10 in a mouse melanoma lung metastasis model. Cancer Lett. 2018; 419: 30-9.
25. Moradian Tehrani R, Verdi J, Noureddini M, Salehi R, Salarinia R, Mosalaei M, Simonian M, Alani B, Ghiasi MR, Jaafari MR, Mirzaei HR, Mirzaei H. Mesenchymal stem cells: A new platform for targeting suicide genes in cancer. J Cell Physiol. 2018; 233(5): 3831-45.
26. Moradian Tehrani R, Mirzaei H, Verdi J, Sahebkar A, Noureddini M, Salehi R, Alani B, Kianmehr M. Chondrogenic differentiation of human scalp adipose-derived stem cells in Polycaprolactone scaffold and using freeze thaw freeze method. J Cell Physiol. 2018; 233(10): 6705-13.
27. Liu J, Yu F, Sun Y, Jiang B, Zhang W, Yang J, Xu GT, Liang A, Liu S. Concise reviews: Characteristics and potential applications of human dental tissue-derived mesenchymal stem cells. Stem Cells. 2015; 33(3): 627-38.
28. Nuti N, Corallo C, Chan BM, Ferrari M, Gerami-Naini B. Multipotent differentiation of human dental pulp stem cells: a literature review. Stem Cell Rev. 2016; 12(5): 511-23.
29. Lee DJ, Tseng HC, Wong SW, Wang Z, Deng M, Ko CC. Dopaminergic effects on in vitro osteogenesis. Bone Res. 2015; 3: 15020.
30. Maharam E, Yaport M, Villanueva NL, Akinyibi T, Laudier D, He Z, Leong DJ, Sun HB. Rho/Rock signal transduction pathway is required for MSC tenogenic differentiation. Bone Res. 2015; 3: 15015.
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Published
2020-06-30
How to Cite
ARBILDO-VEGA, Heber; CRUZADO-OLIVA, Fredy; INFANTES-RUIZ, Edward.
Dental stem cells and their application in dentistry..
Journal of Oral Research, [S.l.], v. 9, n. 3, p. 220-233, june 2020.
ISSN 0719-2479.
Available at: <https://www.joralres.com/index.php/JOralRes/article/view/joralres.2020.039>. Date accessed: 20 apr. 2024.
doi: https://doi.org/10.17126/joralres.2020.039.
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