Comparison of Ostene® and Bone wax on Bone Healing: A Comparative experimental study in rabbits.

  • Huda A. Salim Department of Oral and Maxillo-facial Surgery, College of Dentistry, University of Mosul, Iraq.

Abstract

Introduction: Ostene® is a new synthetic bone hemostatic wax-like inert and biocompatible material that dissolves within two days after application. Bone wax is a well- known topical hemostatic agent, easy to use, and its application is very simple. Wound healing is a complex biological process; Bone is a dynamic tissue that is continuously resorbed, renewed, and remodeled.  Materials and methods: Twenty domestic rabbits were divided into four groups (day 1, day 3, day 7, and day 14). Each rabbit was anaesthetized and three holes were drilled in the mandible: one was filled with Ostene®, another with bone wax, and the other was left unfilled as control. Sites of intervention were assessed by histopathology. Results and Discussion: Ostene® and bone wax showed osteoinductive property in bone healing with no inflammatory reaction. Our study revealed new bone formation within 14 days in Ostene® group. After histopathological analysis and scoring was finished, analysis by SPSS 14 software showed a significant difference between the use of Ostene® and bone wax. Conclusion: Ostene® showed superiority over bone wax in bone healing, and it can be used in the same way as bone wax with no interference with bone healing and osteogenesis. Ostene® has no side effects following application.

References

1. Venkataraman N, Bansal S, Bansal P, Narayan S. Dynamics of bone graft healing around implants. J Int Clin Dent Res Organ. 2015;7(3):40–7.
2. Beriberi A, Samarani A, Nader N, Noujeim Z, Dagher M, Kanj W, Mearawi R, Salemeh Z, Badran B. Physicochemical characteristic of bone substitutes used in oral surgery in comparison to autogenous bone. BioMed Research International. 2014;320790:1–9.
3. Neal D. Peterson's principles of oral and maxillofacial surgery. 2nd Ed. Hamilton, London: Decker Inc; 2004.
4. Khan WS, Rayan F, Dhinsa BS, Marsh D. An Osteoconductive, Osteoinductive, and Osteogenic Tissue-Engineered Product for Trauma and Orthopaedic Surgery:How Far AreWe? Stem Cells Inter. 2012;2012(236231):1–7.
5. Kumar V, Abbas AK, Aster JC. Robbins and Cotran Pathologic Basis of Disease. 8th Ed. Philadelphia: Saunders; 2010.
6. Kalfas IH. Principles of bone healing. Neurosurg Focus. 2001;10(4):E1.
7. Nather A. , Nather A, Ong HJC, Aziz Z. Bone Grafts and Bone Substitutes. Basic Science and Clinical Applications. 1st Ed. Singapore: World Scientific Pub Co Inc; 2005. Structure of Bone; 3–17.
8. Peres JA, Lamano T. Strategies for stimulation of new bone formation: a critical review. Braz Dent J. 2011;22(6):443–8.
9. Li J, Wang HL. Common implant-related advanced bone grafting complications: classification, etiology, and management. Implant Dent. 2008;17(4):389–401.
10. Albrektsson T, Johansson C. Osteoinduction, osteoconduction and osseointegration. Eur Spine J. 2001;10(Suppl 2):S96–101.
11. Wellisz T, An YH, Wen X, Kang Q, Hill CM, Armstrong JK. Infection rates and healing using bone wax and a soluble polymer material. Clin Orthop Relat Res. 2008;466(2):481–6.
12. Sawan A, Elhawary Y, Amer MZ, Rahman MA. Controversial Role of Two Different Local Haemostatic Agents on Bone Healing. J Am Sci. 2010;6(12):155–63.
13. Park J, Koh JW. Era of Bloodless Surgery: Spotlights on Hemostasic Materials and Techniques. Hanyang Med Rev. 2018;38(1):3–15.
14. Kumar S. Local hemostatic agents in the management of bleeding in oral surgery. Asian J Pharm Clin Res. 2016;9(3):35–41.
15. Vestergaard RF, Brüel A, Thomsen JS, Hauge EM, Søballe K, Hasenkam JM. The influence of hemostatic agents on bone healing after sternotomy in a porcine model. Ann Thorac Surg. 2015;99(3):1005–11.
16. Vestergaard RF, Nielsen PH, Terp KA, Søballe K, Andersen G, Hasenkam JM. Effect of hemostatic material on sternal healing after cardiac surgery. Ann Thorac Surg. 2014;97(1):153–60.
17. Magyar CE, Aghaloo TL, Atti E, Tetradis S. Ostene, a new alkylene oxide copolymer bone hemostatic material, does not inhibit bone healing. Neurosurgery. 2008;63(4 Suppl 2):373–8.
18. Armstrong JK, Han B, Kuwahara K, Yang Z, Magyar CE, Dry SM, Atti E, Tetradis S, Fisher TC. The effect of three hemostatic agents on early bone healing in an animal model. BMC Surg. 2010;10:37.
19. Armstrong JK, Han B, Kuwahara K, Yang Z, Magyar CE, Dry SM, Atti E, Tetradis S, Fisher TC. The effect of three hemostatic agents on early bone healing in an animal model. BMC Surg. 2010;10:37.
20. Wellisz T, An YH, Wen X, Kang Q, Hill CM, Armstrong JK. Infection rates and healing using bone wax and a soluble polymer material. Clin Orthop Relat Res. 2008;466(2):481–6.
21. Morrison J. Topical Hemostatic Agents: A Review of the Literature. NOFA J. 2016;3(3)
22. Schonauer C, Tessitore E, Barbagallo G, Albanese V, Moraci A. The use of local agents: bone wax, gelatin, collagen, oxidized cellulose. Eur Spine J. 2004;13(Suppl 1):S89–96.
23. Gurcan O, Gurcay AG, Kazanci A, Onder E, Senturk S, Bavbek M. Is the use of hemostatic matrix (Floseal) and alkylene oxide copolymer (Ostene) safe in spinal laminectomies? Peridural fibrosis assessment. Acta Orthop Traumatol Turc. 2017;51(2):165–8.
24. Raposo-Amaral CE, de Almeida ABA, Paschoal G, Bueno DF, Vulcano LC, Passos-Bueno MR, Alonso N. Histological and radiological changes in cranial bone in the presence of bone wax. Acta Cir Bras. 2011;26(4):274–8.
25. Sudmann B, Anfinsen OG, Bang G, Koppang R, Stølen SØ, Koppang HS, Sudmann E. Assessment in rats of a new bioerodible bone-wax-like polymer. J Acta Orthopaedica Scandinavica. 1993;64(3):336–9.
26. von Arx T, Jensen SS, Hänni S, Schenk RK. Haemostatic agents used in periradicular surgery: an experimental study of their efficacy and tissue reactions. Int Endod J. 2006;39(10):800–8.
27. Nooh N, Abdullah WA, Grawish Mel-A, Ramalingam S, Javed F, Al-Hezaimi K. The effects of surgicel and bone wax hemostatic agents on bone healing: An experimental study. Indian J Orthop. 2014;48(3):319–25.
28. Paknejad M, Rokn AR, Eslami B, Afzalifar R, Safiri A. Evaluation of Three Bone Substitute Materials in the Treatment of Experimentally Induced Defects in Rabbit Calvaria. J Dentistry, Tehran University Med Scie. 2007;4(4):171–6.
29. Kilic N. A Comparison between Medetomidine-Ketamine and Xylazine-Ketamine Anaesthesia in Rabbits. Turk J Vet Anim Sci. 2004;28:921–6.
30. Sultana J, Molla M, Kamal M, Shahidullah M, Bashar M. Histological differences in wound healing in Maxillofacial region in patients with or without risk factors. Bangladesh J Pathology. 2009;24(1):3–8.
31. Solchaga LA, Yoo JU, Lundberg M, Dennis JE, Huibregtse BA, Goldberg VM, Caplan AI. Hyaluronan-based polymers in the treatment of osteochondral defects. J Orthop Res. 2000;18(5):773–80.
32. Vestergaard RF, Jensen H, Vind-Kezunovic S, Jakobsen T, Søballe K, Hasenkam JM. Bone healing after median sternotomy: a comparison of two hemostatic devices. J Cardiothorac Surg. 2010;5:117.
Published
2018-12-28
How to Cite
SALIM, Huda A.. Comparison of Ostene® and Bone wax on Bone Healing: A Comparative experimental study in rabbits.. Journal of Oral Research, [S.l.], v. 7, n. 9, p. 362-367, dec. 2018. ISSN 0719-2479. Available at: <https://www.joralres.com/index.php/JOralRes/article/view/joralres.2018.082>. Date accessed: 29 mar. 2024. doi: https://doi.org/10.17126/joralres.2018.082.
Section
Articles

Keywords

bone hemostatic agents; Ostene; bone wax; bone healing; alkylene oxide copolymers. Agentes hemostáticos óseos; Ostene, cera de hueso; curación ósea; copolímeros de óxido de alquileno.