Relationship between alcoholism addiction and periodontitis. An in vivo study using drinking-in-darkness protocol in rats.
Abstract
Periodontal disease (PD) has been considered a probable risk factor for several systemic diseases. Among them, PD is presumed to be one of the possible etiologies of chronic illness of the central nervous system. In this context, poor oral health and PD is associated with substance abuse in humans. However, if periodontal lesions can produce addiction is unknown. This paper aims to evaluate the possibility that chronic periodontal injury (CPL) can cause ethanol binge intake in drink-in-darkness (DID) protocol in rats. In CPL group (n=10) experimental damage was done to the periodontal tissue of the second maxillary molar, the control group (n=9) received sham injury. Forty-three days after CPL the intake of ethanol was assessed using several concentrations in DID experiment. During the DID experiment, we observed significant differences between the binge-type consumption of ethanol at the lowest concentration of 10% (p=0.01). Differences in consumption of 20% ethanol are observed during a few days (p=0.04), and there are no differences in consumption at 40% concentration of ethanol (p=0.2). It is concluded that chronic periodontal lesion leads to alcoholism in Wistar rats.
References
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2. Petersen PE, Ogawa H. The global burden of periodontal disease: towards integration with chronic disease prevention and control. Periodontol 2000. 2012;60(1):15–39.
3. Tonetti MS, Van Dyke TE, working group 1 of the joint EFP/AAP workshop. Periodontitis and atherosclerotic cardiovascular disease: consensus report of the Joint EFP/AAP Workshop on Periodontitis and Systemic Diseases. J Periodontol. 2013;84(4 Suppl):S24–9.
4. Preshaw PM, Alba AL, Herrera D, Jepsen S, Konstantinidis A, Makrilakis K, Taylor R. Periodontitis and diabetes: a two-way relationship. Diabetologia. 2012;55(1):21–31.
5. Lalla E, Papapanou PN. Diabetes mellitus and periodontitis: a tale of two common interrelated diseases. Nat Rev Endocrinol. 2011;7(12):738–48.
6. Chapple IL, Genco R, working group 2 of the joint EFP/AAP workshop. Diabetes and periodontal diseases: consensus report of the Joint EFP/AAP Workshop on Periodontitis and Systemic Diseases. J Periodontol. 2013;84(4 Suppl):S106–12.
7. Cullinan MP, Seymour GJ. Periodontal disease and systemic illness: will the evidence ever be enough? Periodontol 2000. 2013;62(1):271–86.
8. Bannach SV, Teixeira FB, Fernandes LM, Ferreira RO, Santana LN, Fontes-Júnior EA, Oliveira GB, Prediger RD. Alveolar bone loss induced by chronic ethanol consumption from adolescence to adulthood in Wistar rats. Indian J Exp Biol. 2015;53(2):93–7.
9. Dantas AM, Mohn CE, Burdet B, Zorrilla Zubilete M, Mandalunis PM, Elverdin JC, Fernández-Solari J. Ethanol consumption enhances periodontal inflammatory markers in rats. Arch Oral Biol. 2012;57(9):1211–7.
10. Khocht A, Schleifer S, Janal M, Keller S. Neutrophil function and periodontitis in alcohol-dependent males without medical disorders. J Int Acad Periodontol. 2013;15(3):68–74.
11. Wada-Mihara C, Seto H, Ohba H, Tokunaga K, Kido JI, Nagata T, Naruishi K. Local administration of calcitonin inhibits alveolar bone loss in an experimental periodontitis in rats. Biomed Pharmacother. 2018;97:765–70.
12. Abe T, Hajishengallis G. Optimization of the ligature-induced periodontitis model in mice. J Immunol Methods. 2013;394(1-2):49–54.
13. Rhodes JS, Best K, Belknap JK, Finn DA, Crabbe JC. Evaluation of a simple model of ethanol drinking to intoxication in C57BL/6J mice. Physiol Behav. 2005;84(1):53–63.
14. Bertola A, Mathews S, Ki SH, Wang H, Gao B. Mouse model of chronic and binge ethanol feeding (the NIAAA model) Nat Protoc. 2013;8(3):627–37.
15. Baghaie H, Kisely S, Forbes M, Sawyer E, Siskind DJ. A systematic review and meta-analysis of the association between poor oral health and substance abuse. Addiction. 2017;112(5):765–79.
16. Cury PR, Oliveira MG, Dos Santos JN. Periodontal status in crack and cocaine addicted men: a cross-sectional study. Environ Sci Pollut Res Int. 2017;24(4):3423–9.
17. Mohammadi TM, Hasheminejad N, Salari HR, Rostamizadeh MR, Najafipour H. Association between Tooth Loss and Opium Addiction: Results of a Community-Based Study on 5900 Adult Individuals in South East of Iran in 2015. J Int Soc Prev Community Dent. 2017;7(4):186–90.
18. Saini GK, Gupta ND, Prabhat KC. Drug addiction and periodontal diseases. J Indian Soc Periodontol. 2013;17(5):587–91.
19. Dos Santos Carvalho J, Cardoso Guimarães Vasconcelos AC, Herlany Pereira Alves E, Dos Santos Carvalho A, da Silva FRP, de Carvalho França LF, de Pádua Rocha Nóbrega Neto A, Di Lenardo D, de Souza LKM, Barbosa ALDR, Medeiros JR, de Oliveira JS, Vasconcelos DFP. Steatosis caused by experimental periodontitis is reversible after removal of ligature in rats. J Periodontal Res. 2017;52(5):883–92.
20. Tomofuji T, Sanbe T, Ekuni D, Azuma T, Irie K, Maruyama T, Tamaki N, Yamamoto T. Oxidative damage of rat liver induced by ligature-induced periodontitis and chronic ethanol consumption. Arch Oral Biol. 2008;53(12):1113–8.
21. Erbaş O, Akseki H, Aktuğ H, Taşkıran D. Low-grade chronic inflammation induces behavioral stereotypy in rats. Metab Brain Dis. 2015;30(3):739–46.
22. Otomo-Corgel J, Pucher JJ, Rethman MP, Reynolds MA. State of the science: chronic periodontitis and systemic health. J Evid Based Dent Pract. 2012;12(3 Suppl):20–8.
23. Gaspersic R, Kovacic U, Cör A, Skaleric U. Unilateral ligature-induced periodontitis influences the expression of neuropeptides in the ipsilateral and contralateral trigeminal ganglion in rats. Arch Oral Biol. 2008;53(7):659–65.
24. González-Sepúlveda M, Pozo OJ, Marcos J, Valverde O. Chronic pain causes a persistent anxiety state leading to increased ethanol intake in CD1 mice. J Psychopharmacol. 2016;30(2):188–203.
25. Rodrigues LC, Gobira PH, de Oliveira AC, Pelição R, Teixeira AL, Moreira FA, Campos AC. Neuroinflammation as a possible link between cannabinoids and addiction. Acta Neuropsychiatr. 2014;26(6):334–46.
26. Cui C, Shurtleff D, Harris RA. Neuroimmune mechanisms of alcohol and drug addiction. Int Rev Neurobiol. 2014;118:1–12.
Published
2018-02-27
How to Cite
PÉREZ-MARTÍNEZ, Isaac et al.
Relationship between alcoholism addiction and periodontitis. An in vivo study using drinking-in-darkness protocol in rats..
Journal of Oral Research, [S.l.], v. 7, n. 2, p. 55-60, feb. 2018.
ISSN 0719-2479.
Available at: <https://www.joralres.com/index.php/JOralRes/article/view/joralres.2018.006>. Date accessed: 23 apr. 2024.
doi: https://doi.org/10.17126/joralres.2018.006.
Issue
Section
Articles
Keywords
ethanol; periodontal lesion; addiction; alveolar bone loss; drink-in-darkness.
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