Topography of the inferior alveolar nerve in human embryos and fetuses. An histomorphological study.
Abstract
Abstract: The aim of this study is to establish the position of the inferior alveolar nerve in relation to the Meckel’s cartilage, the anlage of the mandibular body and primordia of the teeth, and also to trace the change in nerve trunk structure in the human prenatal ontogenesis. Serial sections (20µm) from thirty-two 6-12 weeks-old entire human embryos and serial sections (10µm) of six mandibles of 13-20 weeks-old human fetuses without developmental abnormalities were studied. Histological sections were impregnated with silver nitrate according to Bilshovsky-Buke and stained with hematoxylin and eosin. During embryonic development, the number of branches of the inferior alveolar nerve increases and its fascicular structure changes. In conclusion, the architecture of intraosseous canals in the body of the mandible, as well as the location of the foramina, is predetermined by the course and pattern of the vessel/nerve branching in the mandibular arch, even before the formation of bony trabeculae. Particularly, the formation of the incisive canal of the mandible can be explained by the presence of the incisive nerve as the extension of the inferior alveolar nerve. It has also been established that Meckel’s cartilage does not participate in mandibular canal morphogenesis.References
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2. Rodella LF, Buffoli B, Labanca M, Rezzani R. A review of the mandibular and maxillary nerve supplies and their clinical relevance. Arch Oral Biol. 2012;57(4):323–34.
3. Kqiku L, Weiglein AH, Pertl C, Biblekaj R, Städtler P. Histology and intramandibular course of the inferior alveolar nerve. Clin Oral Investig. 2011;15(6):1013–6.
4. Wyganowska-Świątkowska M, Przystańska A. The Meckel’s cartilage in human embryonic and early fetal periods. Anat Sci Int. 2011;86(2):98–107.
5. Radlanski RJ, Renz H, Zimmermann CA, Schuster FP, Voigt A, Heikinheimo K. Chondral ossification centers next to dental primordia in the human mandible: A study of the prenatal development ranging between 68 to 270mm CRL. Ann Anat. 2016;208:49–57.
6. Hutchinson EF, Farella M, Hoffman J, Kramer B. Variations in bone density across the body of the immature human mandible. J Anat. 2017;230(5):679–88.
7. Freitas GB, Silva AF, Morais LA, Silva MBF, Silva TCG, Manhães Jr LRC. Incidence and classification of bifid mandibular canals using cone beam computed tomography. Braz J Oral Sci. 2015;14(4):294–8.
8. Kabak SL, Zhuravleva NV, Melnichenko YM, Savrasova NA. Study of the mandibular incisive canal anatomy using cone beam computed tomography. Surg Radiol Anat. 2017;39(6):647–55.
9. Parada C, Chai Y. Mandible and Tongue Development. Curr Top Dev Biol. 2015;115:31–58.
10. Haas LF, Dutra K, Porporatti AL, Mezzomo LA, De Luca Canto G, Flores-Mir C, Corrêa M. Anatomical variations of mandibular canal detected by panoramic radiography and CT: a systematic review and meta-analysis. Dentomaxillofac Radiol. 2016;45(2):20150310.
11. Khorshidi H, Raoofi S, Ghapanchi J, Shahidi S, Paknahad M. Cone Beam Computed Tomographic Analysis of the Course and Position of Mandibular Canal. J Maxillofac Oral Surg. 2017;16(3):306–11.
12. Massey ND, Galil KA, Wilson TD. Determining position of the inferior alveolar nerve via anatomical dissection and micro-computed tomography in preparation for dental implants. J Can Dent Assoc. 2013;79:d39.
13. Yu SK, Lee MH, Jeon YH, Chung YY, Kim HJ. Anatomical configuration of the inferior alveolar neurovascular bundle: a histomorphometric analysis. Surg Radiol Anat. 2016;38(2):195–201.
14. Hur MS, Kim HC, Won SY, Hu KS, Song WC, Koh KS, Kim HJ. Topography and spatial fascicular arrangement of the human inferior alveolar nerve. Clin Implant Dent Relat Res. 2013;15(1):88–95.
15. Chávez-Lomeli ME, Mansilla Lory J, Pompa JA, Kjaer I. The human mandibular canal arises from three separate canals innervating different tooth groups. J Dent Res. 1996;75(8):1540–4.
16. Rodríguez-Vázquez JF, Verdugo-López S, Murakami G. Venous drainage from the developing human base of mandible including Meckel’s cartilage: the so-called Serres’ vein revisited. Surg Radiol Anat. 2011;33(7):575–81.
Published
2017-11-30
How to Cite
KABAK, Sergey Lvovich; ZHURAVLEVA, Natallia Victorovna; MELNICHENKO, Yuliya Michailovna.
Topography of the inferior alveolar nerve in human embryos and fetuses. An histomorphological study..
Journal of Oral Research, [S.l.], v. 6, n. 11, p. 291-298, nov. 2017.
ISSN 0719-2479.
Available at: <https://www.joralres.com/index.php/JOralRes/article/view/joralres.2017.082>. Date accessed: 18 apr. 2024.
doi: https://doi.org/10.17126/joralres.2017.082.
Issue
Section
Articles
Keywords
mandibular nerve; mandible; embryo research.
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