Platelet yield and recovery following the PRGF-U1 protocol in a Peruvian population.

  • Augusto Aguirre-Aguilar School of Stomatology, Univer-sidad Nacional de Trujillo. Trujillo, Peru.
  • Heber Arbildo-Vega School of Stomatology, Univer-sidad Nacional de Trujillo. Trujillo, Peru. Dental Health Center San Mateo. Trujillo, Peru.
  • Antonio Aguirre-Aguilar School of Stomatology, Univer-sidad Nacional de Trujillo. Trujillo, Peru.

Abstract

Objective: To determine the platelet recovery and yield of the PRGF-U1 protocol in a Peruvian population. Methods: An observational, descriptive and cross-sectional study was conducted with a simple random probability sample of 32 patients who attended the Laboratorio Scalab in Trujillo, Peru. A blood sample was taken from each patient in order to obtain the concentration of platelets and before and after the PRGF-U1 protocol, in order to determine platelet recovery and yield. To compare basal platelet concentrations and platelet recovery and yield with gender and age, the chi-square test, Student's t-distribution and Pearson's correlation coefficient were used considering a significance level of p<0.05. Results: Platelet yield was less than 2.2 in two patients and greater than or equal to 2.2 in 30 patients; platelet recovery was equal to 0.4 in 30 patients and greater than 0.4 in two patients. A statistically significant relationship (p<0.05) between basal platelet count and age was found when comparing basal platelet count, platelet recovery and platelet yield according to gender and age, but no significant relationship between the other variables (p>0.05). Conclusion: The PRGF-U1 protocol presents optimal platelet yield and minimal expected platelet recovery.

References

1. Aguirre A, Arbildo H, Peralta J. Comparative performance of the protocol of plasma rich in growth factors – universal 1 (PRGF-U1) for obtaining platelet rich plasma. J Oral Res. 2017;6(1):16–8.
2. Dhurat R, Sukesh M. Principles and Methods of Preparation of Platelet-Rich Plasma: A Review and Author's Perspective. J Cutan Aesthet Surg. 2014;7(4):189–97.
3. Dhurat R, Sukesh M. Principles and Methods of Preparation of Platelet-Rich Plasma: A Review and Author's Perspective. J Cutan Aesthet Surg. 2014;7(4):189–97.
4. Raeissadat SA, Babaee M, Rayegani SM, Hashemi Z, Hamidieh AA, Mojgani P, Fouladi Vanda H. An overview of platelet products (PRP, PRGF, PRF, etc.) in the Iranian studies. Future Sci OA. 2017;3(4):FSO231.
5. Agrawal AA. Evolution, current status and advances in application of platelet concentrate in periodontics and implantology. World J Clin Cases. 2017;5(5):159–71.
6. Samra DJ, Orchard JW. Patterns of platelet-rich plasma use among Australasian sports physicians. BMJ Open Sport Exerc Med. 2015;1(1):e000054.
7. Forni F, Marzagalli M, Tesei P, Grassi A. Platelet gel: applications in dental regenerative surgery. Blood Transfus. 2013;11(1):102–7.
8. Moreno R, Gaspar Carreño M, Jiménez Torres J, Alonso Herreros JM, Villimar A, López Sánchez P. [Methods to obtain platelet-rich plasma and osteoinductive therapeutic use] Farm Hosp. 2015;39(3):130–6.
9. Biino G, Santimone I, Minelli C, Sorice R, Frongia B, Traglia M, Ulivi S, Di Castelnuovo A, Gögele M, Nutile T, Francavilla M, Sala C, Pirastu N, Cerletti C, Iacoviello L, Gasparini P, Toniolo D, Ciullo M, Pramstaller P, Pirastu M, de Gaetano G, Balduini CL. Age- and sex-related variations in platelet count in Italy: a proposal of reference ranges based on 40987 subjects' data. PLoS One. 2013;8(1):e54289.
10. Troussard X, Vol S, Bardet V, Couaillac JP, Fossat C, Luce JC, Maldonado E, Siguret V, Tichet J, Lantieri O, Luce JC, Maldonado E, Siguret V, Tichet J, Lantieri O, Corberand J, French-Speaking Cellular Hematology Group (Groupe Francophone d'Hématologie Cellulaire, GFHC). Full blood count normal reference values for adults in France. J Clin Pathol. 2014;67(4):341–4.
11. Jones CI. Platelet function and ageing. Mamm Genome. 2016;27(7-8):358–66.
Published
2018-11-27
How to Cite
AGUIRRE-AGUILAR, Augusto; ARBILDO-VEGA, Heber; AGUIRRE-AGUILAR, Antonio. Platelet yield and recovery following the PRGF-U1 protocol in a Peruvian population.. Journal of Oral Research, [S.l.], v. 7, n. 8, p. 282-285, nov. 2018. ISSN 0719-2479. Available at: <https://www.joralres.com/index.php/JOR/article/view/joralres.2018.073>. Date accessed: 02 aug. 2021. doi: https://doi.org/10.17126/joralres.2018.073.
Section
Communications

Keywords

plasma rich in growth factors; platelet count; platelet-rich plasma; regenerative medicine.