Multidimensional study of orofacial chronic neuropathic pain: An experimental study in rats.

Claudia D Montes-Angeles, Nadia Gutierrez, Christian Sosa, Juan Jiménez, Florencio Miranda, Isaac O Pérez-Martinez

Abstract


Orofacial neuropathic chronic pain (NCP) is frequently attributed to lesions caused by orofacial surgeries and dental treatments. There are many experimental models available to study orofacial NCP, however, many are extremely painful for the animal due to the amplitude of the innervated region. A previously proposed mental nerve constriction model, mNC, was used in this project. Forty Wistar rats were randomly divided into two groups: one group included rats with mNC (n=20), and another rats with sham lesions (n=20). Through the use of the fixed ratio program and the progressive program, a decrease of motivation for a sweet substance, caused by the lesion, was evaluated. The possibility of lterations in cognitive learning and adaptation abilities was also assessed using the go/no-go behavioral task. The mNC group showed low induced and spontaneously evoked pain responses, as well as a decrease in the motivation for sucrose, a sign of anhedonia. This decrease does not depend on taste processing. Finally, although no alterations in the learning-memory process were observed, the mNC group did show alterations when adapting to a new rule.

Keywords


neuralgia; facial pain; animal experimentation.

References


Tınastepe N, Oral K. Neuropathic pain after dental treatment. Agri. 2013;25(1):1–6.

Fukuda K, Ichinohe T, Kaneko Y. Pain Management for Nerve Injury following Dental Implant Surgery at Tokyo Dental College Hospital. Int J Dent. 2012;2012:209474.

Dogru Huzmeli E, Melek I. Neuropathic pain’s biopsychosocial effects. Neurol Sci. 2017

Zis P, Daskalaki A, Bountouni I, Sykioti P, Varrassi G, Paladini A. Depression and chronic pain in the elderly: links and management challenges. Clin Interv Aging. 2017;12:709–20.

Vinall J, Pavlova M, Asmundson GJ, Rasic N, Noel M. Mental Health Comorbidities in Pediatric Chronic Pain: A Narrative Review of Epidemiology, Models, Neurobiological Mechanisms and Treatment. Children. 2016;3(4):pii: E40.

Doan L, Manders T, Wang J. Neuroplasticity underlying the comorbidity of pain and depression. Neural Plast. 2015;2015:504691.

Bushnell MC, Case LK, Ceko M, Cotton VA, Gracely JL, Low LA, Pitcher MH, Villemure C. Effect of environment on the longterm consequences of chronic pain. Pain. 2015;156(Suppl 1):S42-9.

Colloca L, Ludman T, Bouhassira D, Baron R, Dickenson AH, Yarnitsky D, Freeman R, Truini A, Attal N, Finnerup NB, Eccleston C, Kalso E, Bennett DL, Dworkin RH, Raja SN. Neuropathic pain. Nat Rev Dis Primers. 2017;3:17002.

Wijma AJ, van Wilgen CP, Meeus M, Nijs J. Clinical biopsychosocial physiotherapy assessment of patients with chronic pain: The first step in pain neuroscience education. Physiother Theory Pract. 2016;32(5):368–84.

Ding W, You Z, Shen S, Yang J, Lim G, Doheny JT, Chen L, Zhu S, Mao J. An Improved Rodent Model of Trigeminal Neuropathic Pain by Unilateral Chronic Constriction Injury of Distal Infraorbital Nerve. J Pain. 2017;18(8):899–907.

Deseure K, Hans GH. Chronic Constriction Injury of the Rat’s Infraorbital Nerve (IoN-CCI) to Study Trigeminal Neuropathic Pain. J Vis Exp. 2015;(103):e53167.

Deseure K, Hans G. Behavioral study of non-evoked orofacial pain following different types of infraorbital nerve injury in rats. Physiol Behav. 2015;138:292–6.

Lynds R, Lyu C, Lyu GW, Shi XQ, Rosén A, Mustafa K, Shi TJS. Neuronal plasticity of trigeminal ganglia in mice following nerve injury. J Pain Res. 2017;10:349–57.

Ma F, Zhang L, Oz HS, Mashni M, Westlund KN. Dysregulated TNFα promotes cytokine proteome profile increases and bilateral orofacial hypersensitivity. Neuroscience. 2015;300:493–507.

Challa SR. Surgical animal models of neuropathic pain: Pros and Cons. Int J Neurosci. 2015;125(3):170–4.

Grelik C, Bennett GJ, Ribeiro-da-Silva A. Autonomic fibre sprouting and changes in nociceptive sensory innervation in the rat lower lip skin following chronic constriction injury. Eur J Neurosci. 2005;21(9):2475–87.

HODOS W. Progressive ratio as a measure of reward strength. Science. 1961;134(3483):943–4.

Kniffin TC, Danaher RJ, Westlund KN, Ma F, Miller CS, Carlson CR. Persistent neuropathic pain influences persistence behavior in rats. J Oral Facial Pain Headache. 2015;29(2):183–92.

Carlson CR. Psychological considerations for chronic orofacial pain. Oral Maxillofac Surg Clin North Am. 2008;20(2):185–95.


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