Clinical effect of platelet rich plasma in the treatment of periodontal intrabony defects. Systematic review and meta-analysis.

  • Heber Arbildo Escuela de Odontología, Universidad Particular de Chiclayo. Chiclayo. Escuela de Estomatología, Universidad Señor de Sipán. Chiclayo. Centro de Salud Odontológico San Mateo. Trujillo.
  • Luis Gamarra Escuela de Estomatología, Universidad Privada Antonio Guillermo Urrelu. Cajamarca. Facultad de Estomatología, Universidad Nacional de Trujillo. Trujillo.
  • Sandra Rojas Facultad de Estomatología, Universidad Nacional de Trujillo. Trujillo.
  • Edwars Infantes Escuela de Estomatología, Universidad Señor de Sipán. Chiclayo. Escuela de Estomatología, Universidad Privada Antonio Guillermo Urrelu. Cajamarca Escuela de Estomatología, Universidad César Vallejo. Piura.
  • Cèsar Lamas Escuela de Odontología, Universidad Católica los Ángeles de Chimbote. Chimbote.
  • Hernán Vásquez Facultad de Odontología, Universidad San Martín de Porres. Lima.


Introduction: One of the consequences of periodontitis is periodontal intrabony defects (PID). Various biomaterials have been used for its treatment, but there is still no biomaterial considered as the gold standard. Current research is focused on the use of platelet-rich plasma (PRP) for the treatment of PID. Objective: To determine the clinical effect of PRP in the treatment of PID through a systematic review with meta-analysis. Materials and Methods: A literature search was conducted until February 2017 in the biomedical databases: Pubmed, Embase, Scielo, Science Direct, SIGLE, LILACS, IBECS, and the Cochrane Central Register of Clinical Trials. The criteria for the selection of the studies, which were randomized clinical trials, were the following: articles or papers published in the last 5 years, reporting clinical effects, with a follow-up time equal to or greater than 6 months, and a sample size equal to or greater than 10 patients reporting the use of PRP as a treatment for PID. The methodological quality of the studies was analyzed using the Cochrane Handbook of Systematic Reviews of Interventions as a reference. Results: The search strategy yielded nine articles reporting a reduction in probing depth and gingival recession, and an increase in clinical insertion level when using PRP alone or in combination with another biomaterial. Conclusion: The reviewed literature suggests that the use of PRP in the treatment of PID has a positive clinical effect.


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How to Cite
ARBILDO, Heber et al. Clinical effect of platelet rich plasma in the treatment of periodontal intrabony defects. Systematic review and meta-analysis.. Journal of Oral Research, [S.l.], v. 6, n. 4, p. 97-104, apr. 2017. ISSN 0719-2479. Available at: <>. Date accessed: 21 sep. 2021. doi:


platelet-rich plasma; periodontitis; review; meta-analysis.

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