Oral and systemic manifestations of congenital hypothyroidism in children. A case report.

Carmen Ayala, Obed Lemus, Maribel Frías


Hypothyroidism is the most common thyroid disorder. It may be congenital if the thyroid gland does not develop properly. A female predominance is characteristic. Hypothyroidism is the most common congenital pediatric disease and its first signs and early symptoms can be detected with neonatal screening. Some of the oral manifestations of hypothyroidism are known to be: glossitis, micrognathia, macroglossia, macroquelia, anterior open bite, enamel hypoplasia, delayed tooth eruption, and crowding. This paper briefly describes the systemic and oral characteristics of congenital hypothyroidism in a patient being treated at a dental practice. The patient had early childhood caries and delayed tooth eruption. There are no cases of craniosynostosis related to the primary pathology, which if left untreated, increases the cranial defect. Early diagnosis reduces the clinical manifestations of the disease. Delayed tooth eruption will become a growing problem if the patient does not receive timely treatment and monitoring.


Congenital Hypothyroidism; Oral Manifestations; Neonatal Screening; early childhood caries.


Grob F, Martínez-Aguayo F: Hipotiroidismo congénito: un diagnóstico que no debemos olvidar. Rev Chil Pediatr. 2012; 83 (5): 482-91.

Olivieri A, Fazzini C, Medda E, Italian Study Group for Congenital Hypothyroidism. Multiple factors influencing the incidence of congenital hypothyroidism detected by neonatal screening. Horm Res Paediatr. 2015; 83(2): 86-93.

Corbetta C, Luisella A. Laboratory Aspects in Neonatal Screening of Congenital Hypothyroidism. In: Bona G, De Luca F, Monzani A. Editores. Thyroid Diseases in Childhood, 1ª. Ed. Naples: Springer International Publishing; 2015.

Baş VN, Aycan Z, Cangul H, Kendall M, Ağladıoğlu SY, Çetinkaya S, Maher ER. A common thyroid peroxidase gene mutation (G319R) in Turkish patients with congenital hypothyroidism could be due to a founder effect. J Pediatr Endocrinol Metab. 2014; 27(3-4): 383-87.

Kurtoğlu S, Köroğlu Ş, Baştuğ O, Daar G, Yıkılmaz A, Elmalı F. The comparison of thyroxine versus thyroxine plus oral iodine in the treatment of congenital hypothyroidism due to iodine deficiency. Horm Res Paediatr. 2014; 81(6), 409-15.

Mayayo E, Puga B, Valle Labarta JL, Ferrández A. Desarrollo psicomotor en el hipotiroidismo congénito. En: Diéguez C, Yturriaga R. Editores. Actualizaciones en Endocrinología: Tiroides. 3ª. Ed. Madrid: McGraw-Hill Interamericana; 2007.

Ferrazzo KL, Payeras MR, Ferrazzo VA, Mezomo MB. Craniofacial and dental manifestations of triple X syndrome associated with congenital hypothyroidism: a case report. Spec Care Dent. 2014; 34(3): 156-59.

Tovar N, Rojas A, Torres F, Susaya R, Del Águila C, Falen JM. Edad de Diagnóstico Clínico del Hipotiroideo Congénito: Veinte Años Después. Rev Peru Pediatr. 2014; 67(1): 17-21.

Arnao MDR, Sánchez AR, Dulín E. Detección precoz de alteraciones endocrinas. Rev Esp Endocrinol Pediatr. 2013; 4(S1): 87-99.

Suma GN, Lakhanpal M, Dhillon M, Srivastava S. Orofacial manifestations of congenital hypothyroidism: Clinicoradiological case report. J Indian Acad Oral Med Radiol. 2014; 26:111-14.

Rastogi MV, LaFranchi HS. Congenital hypothyroidism. Orphanet J Rare Dis. 2010; 5(17): 1-22.

Fontes D, Natoli Ó, Pinyot J. Estudio de la craneosinostosis por tomografía computarizada. Imagen Diag. 2011; 2(2): 47-52.

Bernal J. Hormonas tiroideas y desarrollo cerebral. Rev Esp Endocrinol Pediatr. 2014; 5(2): 5-8.

Lazarus J, Brown R, Daumerie C, Hubalewska-Dydejczyk A, Negro R, Vaidya B. 2014 European Thyroid Association guidelines for the management of subclinical hypothyroidism in pregnancy and in children. Eur Thyroid J. 2014; 3(2):76-94

Grau G, Aguayo A, Vela A, Aniel-Quiroga A, Espada M, Miranda G, Rica I. Normal intellectual development in children born from women with hypothyroxinemia during their pregnancy. J Trace Elem Med Biol. 2015; 31(7): 18-24.

Su PY, Huang K, Hao JH, et al. Maternal thyroid function in the first twenty weeks of pregnancy and subsequent fetal and infant development: A prospective population-based cohort study in China. J Clin Endocrinol Metab. 2011; 96:3234-41.

Stagnaro-Green A, Abalovich M, Alexander E, Azizi F, Mestman J, Negro R, Nixon A, Pearce EN, Soldin OP, Sullivan S, Wiersinga W. Guidelines of the American Thyroid Association for the diagnosis and management of thyroid disease during pregnancy and postpartum. Thyroid. 2011; 21(10): 1081-125.

Grüters A, Krude H. Detection and treatment of congenital hypothyroidism. Nat Rev Endocrinol. 2012; 8(2):104-13.

Vitalle M, Weiler RM, Niskier S, Braga JA. Atraso na erupção dental em adolescente com hipotireoidismo. Rev Paul Pediatr. 2012; 30(4): 613-16.

Vani S, Nooney A, Raju KS, Hemadri M. Idiopathic multiple unerupted permanent teeth: A rare case report. J Dr NTR Univ Health Sci. 2014; 3(4): 283-6.

Full Text: PDF


  • There are currently no refbacks.

Creative Commons License
This work is licensed under a Creative Commons Attribution 3.0 License.

Corresponding: Facultad de Odontología, Universidad de Concepción, Chile. Roosevelt 1550, Concepción, Chile. Phone +56-41-2204232 - E-mail journal@joralres.com.