Parry-Romberg syndrome in a pediatric patient. A case report.

Edgar Reyes, Carmen de la Luz Ayala, Lizzete Ríos


The Parry-Romberg syndrome is a rare degenerative disease of unknown etiology that has dental implications. It is characterized by a progressive hemifacial atrophy that appears in the early stages of life. It causes aesthetic, functional and psychological alterations, and has social implications for the patient. There is no definitive treatment for the Parry-Romberg syndrome.  Systemic and immune alterations produce oral and maxillofacial manifestations, which need to be managed by specialized dental professionals. The aim of this paper is to do a literature review of the Parry-Romberg syndrome and describe the oral and clinical characteristics of this condition in a 12-year-old male pediatric patient, who had a history of neurological disorders and facial asymmetry on the left side. Dentists require an adequate knowledge of the clinical and dental characteristics of this syndrome.  With early diagnosis and appropriate surgical and orthodontic treatment at an early age, they can improve the quality of life of patients and minimize invasive long-term effects.


Parry-Romberg syndrome; facial asymmetry; progressive facial hemiatrophy; oral manifestations.


Longo D, Paonessa A, Specchio N, Delfino LN, Claps D, Fusco L, Fariello G. Parry-Romberg syndrome and Rasmussen encephalitis: possible association. Clinical and neuroimaging features. J Neuroimaging 2011; 21(2): 188-93.

da Silva Pinheiro TP, Camarinha-da Silva C, Limeira-da Silveira C S, Ereno-Botelho PC, Rodrigues-Pinheiro MDG, Viana-Pinheiro JDJ. Progressive hemifacial atrophy. Case report. Med Oral Patol Oral Cir Bucal 2006; 11(4): 112-14.

Kumar A, Kumar R, Subash GP, Aloogopinathan G. Progressive hemifacial atrophy Parry Romberg syndrome presenting as severe facial pain in a young man: a case report. Cases J. 2009; (2): 677-81.

Budrewicz S, Koszewicz M, Koziorowska-Gawron E, Szewczyk P, Podemski R, Sotwinski K. Parry-Romberg syndrome: clinical, electrophysiological and neuroimaging correlations. Neurol Sci. 2012; 33(2): 423-27.

Dalla G, Colombo B, Dalla D, Martinelli V, Comi G. (2013). Parry Romberg Syndrome associated with chronic facial pain. J Clin Neurosci. 2013; 20(9): 1320-22.

Baca SIM, Merino JE, Pérez DA. Esclerodermia localizada: corrección mediante trasplante autólogo de grasa. Comunicación de seis casos. Dermatol Rev Mex. 2013; 57(1): 60-3.

Devani P, Lal H, Thakral A. Parry–Romberg Syndrome: A Case Report. Nepalese J Radiol. 2014; 4(1): 67-70.

Khan M, Khan M, Negi R, Gupta N. Parry Romberg Syndrome with localized scleroderma: a case report. J Clin Exp Dent. 2014; 6(3): 313–16.

Nasser O, Greiner K, Amer R. Unilateral optic atrophy preceding Coats Disease in a girl with Parry-Romberg syndrome. Eur J Ophthalmol. 2010; 20(1): 221-23.

Doolittle DA, Lehman VT, Schwartz KM, Wong-Kisiel LC, Lehman JS, Tollefson MM. CNS imaging findings associated with Parry–Romberg syndrome and en coup de sabre: correlation to dermatologic and neurologic abnormalities. Neuroradiology 2014; 57(1): 21-34.

Paprocka J, Jamroz E, Adamek D, Marszal E, Mandera M. Difficulties in differentiation of Parry-Romberg syndrome, unilateral facial sclerodermia, and Rasmussen syndrome. Childs Nerv Syst. 2006; 22(4): 409-15.

Rangare AL, Babu SG, Thomas PS, Shetty SR. Parry-Romberg syndrome: a rare case report. J Oral Maxillofac Surg. 2011; 2(2): 1-5.

Sujatha SR, Devaraju D, Kunal A. Parry Romberg syndrome: Report of two cases with rare dental and skeletal findings. e-J Dent. 2012; 2(3): 212-15.

El-Kehdy J, Abbas O, Rubeiz N. A review of Parry-Romberg syndrome. J Am Acad Dermatol. 2012; 67(4): 769-84.

González ME, Cruz Y, García B, Vergara L, Mena L. Parry-Romberg's syndrome: View of its treatment. Rev Cubana Estomatol. 2005; 42(2): 1-7.

Nerdi T, Marques J, Tamires A, Peres F, Rodrigues C, Appenzeller S. Neurologic involvement is scleroderma en coup de sabre. Autoimmune Dis. 2012; 43(3): 335-47.

González, NTC, Linares LEH, Escobar PCA, Barrios MF. Síndrome de Parry-Romberg o hemiatrofia facial progresiva. Reporte de un caso. Rev Ciencia Odont. 2012; 9(1): 56-63.

Al-Aizari NA, Azzeghaiby SN, Al-Shamiri H M, Darwish S, Tarakji B. Oral manifestations of Parry–Romberg syndrome: A review of literature. Avicenna J Med. 2015; 5(2): 25-28.

Scolozzi P, Herzog G. Total mandibular subapical osteotomy and le fort I osteotomy using piezosurgery and computer-aided designed and manufactured surgical splints: a favorable combination of three techniques in the management of severe mouth asymmetry in Parry-Romberg syndrome. J Oral Maxillofac Surg. 2014; 72(5): 991-99.

You KH, Baik HS. Orthopedic and orthodontic treatment of Parry-Romberg syndrome. J Craniofac Surg. 2011; 22(3): 970-73.

Full Text: PDF


  • There are currently no refbacks.

Creative Commons License
This work is licensed under a Creative Commons Attribution 3.0 License.

Corresponding: Facultad de Odontología, Universidad de Concepción, Chile. Roosevelt 1550, Concepción, Chile. Phone +56-41-2204232 - E-mail